Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 윤혜전 | * |
dc.date.accessioned | 2016-08-27T04:08:10Z | - |
dc.date.available | 2016-08-27T04:08:10Z | - |
dc.date.issued | 2016 | * |
dc.identifier.issn | 0938-7994 | * |
dc.identifier.issn | 1432-1084 | * |
dc.identifier.other | OAK-15660 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/217622 | - |
dc.description.abstract | To prospectively compare performances of single-voxel proton magnetic resonance spectroscopy (H-1-MRS) and F-18-fluorodeoxyglucose positron emission tomography (FDG-PET) in predicting pathologic response to neoadjuvant chemotherapy (NAC) in breast cancer patients. Thirty-five breast cancer patients who received NAC and subsequent surgery were prospectively enrolled. MRS and FDG-PET were performed before and after the 1st NAC cycle. Percentage changes of total choline-containing compounds (tCho) via MRS, and maximum and peak standardized uptake values (SUVmax, SUVpeak) and total lesion glycolysis (TLG) via FDG-PET were measured, and their performances in predicting pathologic complete response (pCR) were compared. Of the 35 patients, 6 showed pCR and 29 showed non-pCR. Mean % reductions of tCho, SUVmax, SUVpeak, and TLG of the pCR group were larger than those of the non-pCR group (-80.3 +/- 13.9 % vs. -32.1 +/- 49.4 %, P = 0.025; -54.7 +/- 22.1 % vs. -26.3 +/- 33.7 %, P = 0.058; -60.7 +/- 18.3 % vs. -32.3 +/- 23.3 %, P = 0.009; -89.5 +/- 8.5 % vs. -52.6 +/- 36.2 %, P = 0.020). Diagnostic accuracy (area under ROC curve; Az, 0.911) of the % reduction of tCho was comparable to those of %SUVmax (0.822), SUVpeak (0.862), and TLG (0.879) in distinguishing pCR from non-pCR (all P > 0.05). MRS showed comparable performance to FDG-PET in early prediction of pCR in breast cancer patients. aEuro cent MRS can predict response to NAC in breast cancer post-1 (st) cycle. aEuro cent Changes in tCho and SUV after NAC reflect tumour cellularity changes. aEuro cent MRS can be an alternative to FDG-PET in predicting response to NAC. | * |
dc.language | English | * |
dc.publisher | SPRINGER | * |
dc.subject | Breast neoplasm | * |
dc.subject | Magnetic resonance imaging | * |
dc.subject | Magnetic resonance spectroscopy | * |
dc.subject | Positron emission tomography | * |
dc.subject | Neoadjuvant chemotherapy | * |
dc.title | Early prediction of response to neoadjuvant chemotherapy in breast cancer patients: comparison of single-voxel H-1-magnetic resonance spectroscopy and F-18-fluorodeoxyglucose positron emission tomography | * |
dc.type | Article | * |
dc.relation.issue | 7 | * |
dc.relation.volume | 26 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 2279 | * |
dc.relation.lastpage | 2290 | * |
dc.relation.journaltitle | EUROPEAN RADIOLOGY | * |
dc.identifier.doi | 10.1007/s00330-015-4014-7 | * |
dc.identifier.wosid | WOS:000377996200034 | * |
dc.identifier.scopusid | 2-s2.0-84941670486 | * |
dc.author.google | Cho, Nariya | * |
dc.author.google | Im, Seock-Ah | * |
dc.author.google | Kang, Keon Wook | * |
dc.author.google | Park, In-Ae | * |
dc.author.google | Song, In Chan | * |
dc.author.google | Lee, Kyung-Hun | * |
dc.author.google | Kim, Tae-Yong | * |
dc.author.google | Lee, Hyunjong | * |
dc.author.google | Chun, In Kook | * |
dc.author.google | Yoon, Hai-Jeon | * |
dc.author.google | Moon, Woo Kyung | * |
dc.contributor.scopusid | 윤혜전(47161772300) | * |
dc.date.modifydate | 20240222164135 | * |