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dc.contributor.author곽혜선-
dc.date.accessioned2016-08-27T04:08:10Z-
dc.date.available2016-08-27T04:08:10Z-
dc.date.issued2015-
dc.identifier.issn1462-2416-
dc.identifier.issn1744-8042-
dc.identifier.otherOAK-15654-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/217619-
dc.description.abstractThis study aimed to investigate an association between c-Myc SNPs and stable warfarin doses. Materials & methods: The influences of genetic polymorphisms on dose requirements were investigated by genotyping ten SNPs in 201 patients with stable warfarin doses; VKORC1 (rs9923231), CYP2C9 (rs1057910), CYP4F2 (rs2108622), GATA4 (rs10090884), c-Myc (rs4645962, rs4645943, rs4645948 and rs4645974) and 8q24 (rs1447295 and rs16901979). Results: Around 44.3% of the overall interindividual variability in warfarin dose requirements was explained by the multivariate regression model; VKORC1 genotype accounted for 26.4%, CYP2C9 genotype for 4.9%, age for 3.4%, c-Myc genotypes for 5.2% (rs4645974 for 2.4% and rs4645943 for 2.8%), CYP4F2 genotype for 2.9% and diuretic use for 1.5%. Conclusion: Our results revealed that c-Myc could be a determinant of stable warfarin doses.-
dc.languageEnglish-
dc.publisherFUTURE MEDICINE LTD-
dc.subject8q24-
dc.subjectc-Myc-
dc.subjecttranscription factor-
dc.subjectVKORC1-
dc.subjectwarfarin-
dc.titleEffects of single nucleotide polymorphisms in c-Myc on stable warfarin doses in patients with cardiac valve replacements-
dc.typeArticle-
dc.relation.issue10-
dc.relation.volume16-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage1101-
dc.relation.lastpage1108-
dc.relation.journaltitlePHARMACOGENOMICS-
dc.identifier.doi10.2217/PGS.15.37-
dc.identifier.wosidWOS:000361140600007-
dc.identifier.scopusid2-s2.0-84941628487-
dc.author.googleLee, Kyung E.-
dc.author.googleChang, Byung C.-
dc.author.googlePark, Sunny-
dc.author.googleGwak, Hye S.-
dc.contributor.scopusid곽혜선(6601996377)-
dc.date.modifydate20190901081003-
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약학대학 > 약학과 > Journal papers
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