Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 황금숙 | * |
dc.date.accessioned | 2016-08-27T04:08:01Z | - |
dc.date.available | 2016-08-27T04:08:01Z | - |
dc.date.issued | 2015 | * |
dc.identifier.issn | 0731-7085 | * |
dc.identifier.issn | 1873-264X | * |
dc.identifier.other | OAK-15517 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/217532 | - |
dc.description.abstract | Myocardial infarction (MI), a leading cause of death worldwide, results from prolonged myocardial ischemia with necrosis of myocytes due to a blood supply obstruction to an area of the heart. Many studies have reported gender-related differences in the clinical features of MI, but the reasons for these differences remain unclear. In this study, we applied ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry (UPLC/Q-TOF MS) and various statistical methods-such as multivariate, pathway, and correlation analyses to identify gender-specific metabolic patterns in polar metabolites in serum from healthy individuals and patients with MI. Patients with diagnosed MI (n =68), and age- and body mass index-matched healthy individuals (n = 68), were included in this study. The partial least-squares discriminant analysis (PLS-DA) model was generated from metabolic profiling data, and the score plots showed a significant gender-related difference in patients with MI. Many pathways were associated with amino acids and purines; amino acids, acylcarnitines, and purines differed significantly between male and female patients with MI. This approach could be utilized to observe gender-specific metabolic pattern differences between healthy controls and patients with MI. (C) 2015 Elsevier B.V. All rights reserved. | * |
dc.language | English | * |
dc.publisher | ELSEVIER SCIENCE BV | * |
dc.subject | Myocardial infarction | * |
dc.subject | Gender-related differences | * |
dc.subject | Metabolic profiling | * |
dc.subject | UPLC/Q-TOF MS | * |
dc.title | LC/MS-based polar metabolite profiling reveals gender differences in serum from patients with myocardial infarction | * |
dc.type | Article | * |
dc.relation.volume | 115 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 475 | * |
dc.relation.lastpage | 486 | * |
dc.relation.journaltitle | JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | * |
dc.identifier.doi | 10.1016/j.jpba.2015.08.009 | * |
dc.identifier.wosid | WOS:000363439500060 | * |
dc.identifier.scopusid | 2-s2.0-84939806405 | * |
dc.author.google | Lee, Jueun | * |
dc.author.google | Jung, Youngae | * |
dc.author.google | Park, Ju Yeon | * |
dc.author.google | Lee, Sang-Hak | * |
dc.author.google | Ryu, Do Hyun | * |
dc.author.google | Hwang, Geum-Sook | * |
dc.contributor.scopusid | 황금숙(7202676099) | * |
dc.date.modifydate | 20240222154747 | * |