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Developing Streptomyces venezuelae as a cell factory for the production of small molecules used in drug discovery
- Title
- Developing Streptomyces venezuelae as a cell factory for the production of small molecules used in drug discovery
- Authors
- Kim, Eun Ji; Yang, Inho; Yoon, Yeo Joon
- Ewha Authors
- 윤여준
- SCOPUS Author ID
- 윤여준
- Issue Date
- 2015
- Journal Title
- ARCHIVES OF PHARMACAL RESEARCH
- ISSN
- 0253-6269
1976-3786
- Citation
- ARCHIVES OF PHARMACAL RESEARCH vol. 38, no. 9, pp. 1606 - 1616
- Keywords
- Secondary metabolism; Heterologous expression; S. venezuelae; Pathway engineering
- Publisher
- PHARMACEUTICAL SOC KOREA
- Indexed
- SCIE; SCOPUS; KCI
- Document Type
- Review
- Abstract
- The heterologous expression of biosynthetic pathways is an indispensable tool for drug discovery and development from natural products. Streptomyces venezuelae is a promising heterologous host as it offers several attractive advantages, such as rapid growth rate, convenient genetic manipulation, and an abundant supply of common biosynthetic building blocks. In recent decades, several S. venezuelae mutant strains have been constructed and used to facilitate the synthesis and derivatization of diverse natural products. In this review article, we have provided a schematic look at these host strains, which were used to synthesize natural products from genetically engineered biosynthetic gene clusters.
- DOI
- 10.1007/s12272-015-0638-z
- Appears in Collections:
- 자연과학대학 > 화학·나노과학전공 > Journal papers
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