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dc.contributor.author안종균-
dc.date.accessioned2016-08-27T04:08:49Z-
dc.date.available2016-08-27T04:08:49Z-
dc.date.issued2015-
dc.identifier.issn2374-4235-
dc.identifier.issn2374-4243-
dc.identifier.otherOAK-15315-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/217408-
dc.description.abstractBackground: The 10-valent pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) and the 13-valent pneumococcal conjugate vaccine (PCV13) replaced the 7-valent PCV (PCV7) in May 2010 in Korea. We investigated the dynamics of pneumococcal nasopharyngeal (NP) colonization in children with a respiratory illness before and after use of PHiD-CV and PCV13. Methods: From March 2009 to December 2012 NP secretions were obtained from 2176 children aged < 5 years with respiratory diseases. We used the multiplex polymerase chain reaction (PCR) technique to determine pneumococcal serotypes. Results: Among the samples, 468 (21.5%) specimens were positive by multiplex PCR. The overall pneumococcal colonization rate remained stable during the 2009-2012 periods. The serotypes present in PCV7 and serotype 19A decreased in frequency from 36.8% and 26.4% in 2009 to 10.1% and 11.4% in 2012, respectively (chi(2) for trend, P < 0.001 and P = 0.007, respectively). The frequency of non-PCV13 serotypes increased from 36.8% in 2009 to 78.5% in 2012 (chi(2) for trend, P = 0.001). There was no significant difference in carriage rates of each serotype between groups of children that received PCV7, PHiD-CV, or PCV13. Conclusions: Compared with the period of PCV7 vaccination, overall carriage rate was not affected by the introduction of new PCVs. However, serotype distribution now consists mostly of non-vaccine serotypes. PCVs affect mucosal immunity against Streptococcus pneumoniae (SP) in NP carriage; but, global SP colonization seems to be maintained by replacement.-
dc.languageEnglish-
dc.publisherINFORMA HEALTHCARE-
dc.subjectStreptococcus pneumoniae-
dc.subjectserotype-
dc.subjectpneumococcal conjugate vaccine-
dc.subjectnasopharyngeal colonization-
dc.titleChanges in pneumococcal nasopharyngeal colonization among children with respiratory tract infections before and after use of the two new extended-valency pneumococcal conjugated vaccines-
dc.typeArticle-
dc.relation.issue6-
dc.relation.volume47-
dc.relation.indexSCI-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage385-
dc.relation.lastpage392-
dc.relation.journaltitleINFECTIOUS DISEASES-
dc.identifier.doi10.3109/00365548.2014.1001997-
dc.identifier.wosidWOS:000357737400005-
dc.author.googleAhn, Jong Gyun-
dc.author.googleChoi, Seong Yeol-
dc.author.googleKim, Dong Soo-
dc.author.googleKim, Ki Hwan-
dc.contributor.scopusid안종균(55486498300;57207866485)-
dc.date.modifydate20220112142829-
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