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dc.contributor.author안영호*
dc.date.accessioned2016-08-27T04:08:37Z-
dc.date.available2016-08-27T04:08:37Z-
dc.date.issued2014*
dc.identifier.issn2041-1723*
dc.identifier.otherOAK-15062*
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/217282-
dc.description.abstractImmunosuppression of tumour-infiltrating lymphocytes (TIL) is a common feature of advanced cancer, but its biological basis has remained obscure. We demonstrate here a molecular link between epithelial-to-mesenchymal transition (EMT) and CD8(+) TIL immunosuppression, two key drivers of cancer progression. We show that microRNA-200 (miR-200), a cell-autonomous suppressor of EMT and metastasis, targets PD-L1. Moreover, ZEB1, an EMTactivator and transcriptional repressor of miR-200, relieves miR-200 repression of PD-L1 on tumour cells, leading to CD8(+) T-cell immunosuppression and metastasis. These findings are supported by robust correlations between the EMT score, miR-200 levels and PD-L1 expression in multiple human lung cancer datasets. In addition to revealing a link between EMT and T-cell dysfunction, these findings also show that ZEB1 promotes metastasis through a heretofore unappreciated cell non-autonomous mechanism, and suggest that subgroups of patients in whom malignant progression is driven by EMT activators may respond to treatment with PD-L1 antagonists.*
dc.languageEnglish*
dc.publisherNATURE PUBLISHING GROUP*
dc.titleMetastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression*
dc.typeArticle*
dc.relation.volume5*
dc.relation.indexSCI*
dc.relation.indexSCIE*
dc.relation.indexSCOPUS*
dc.relation.journaltitleNATURE COMMUNICATIONS*
dc.identifier.doi10.1038/ncomms6241*
dc.identifier.wosidWOS:000354989000002*
dc.author.googleChen, Limo*
dc.author.googleGibbons, Don L.*
dc.author.googleGoswami, Sangeeta*
dc.author.googleCortez, Maria Angelica*
dc.author.googleAhn, Young-Ho*
dc.author.googleByers, Lauren A.*
dc.author.googleZhang, Xuejun*
dc.author.googleYi, Xiaohui*
dc.author.googleDwyer, David*
dc.author.googleLin, Wei*
dc.author.googleDiao, Lixia*
dc.author.googleWang, Jing*
dc.author.googleRoybal, Jonathon D.*
dc.author.googlePatel, Mayuri*
dc.author.googleUngewiss, Christin*
dc.author.googlePeng, David*
dc.author.googleAntonia, Scott*
dc.author.googleMediavilla-Varela, Melanie*
dc.author.googleRobertson, Gordon*
dc.author.googleJones, Steve*
dc.author.googleSuraokar, Milind*
dc.author.googleWelsh, James W.*
dc.author.googleErez, Baruch*
dc.author.googleWistuba, Ignacio I.*
dc.author.googleChen, Lieping*
dc.author.googlePeng, Di*
dc.author.googleWang, Shanshan*
dc.author.googleUllrich, Stephen E.*
dc.author.googleHeymach, John V.*
dc.author.googleKurie, Jonathan M.*
dc.author.googleQin, F. Xiao-Feng*
dc.contributor.scopusid안영호(7202402440)*
dc.date.modifydate20240222132209*
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의과대학 > 의학과 > Journal papers
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