Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김유리 | * |
dc.date.accessioned | 2016-08-27T04:08:34Z | - |
dc.date.available | 2016-08-27T04:08:34Z | - |
dc.date.issued | 2015 | * |
dc.identifier.issn | 1422-0067 | * |
dc.identifier.other | OAK-15003 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/217250 | - |
dc.description.abstract | A rare subpopulation of cancer cells, termed cancer stem cells (CSCs), may be responsible for tumor relapse and resistance to conventional chemotherapy. The development of a non-toxic, natural treatment for the elimination of CSCs is considered a strategy for cancer treatment with minimal side effects. In the present study, the potential for Sasa quelpaertensis leaf extract (SQE) and its two bioactive compounds, tricin and p-coumaric acid, to exert anti-CSC effects by suppressing cancer stemness characteristics were evaluated in colon cancer cells. CD133(+)CD44(+) cells were isolated from HT29 and HCT116 cell lines using flow-activated cell sorting (FACs). SQE treatment was found to significantly suppress the self-renewal capacity of both cell lines. SQE treatment was also associated with the down-regulation of -catenin and phosphorylated GSK3, while significantly enhancing cell differentiation by up-regulating CK20 expression and blocking the expression of several stem cell markers, including DLK1, Notch1, and Sox-2. In vivo, SQE supplementation suppressed tumor growth in a xenograft model by down-regulating stem cell markers and -catenin as well as HIF-1 signaling. Compared with two bioactive compounds of SQE, SQE exhibited the most effective anti-CSC properties. Taken together, these results provide evidence that SQE inhibits colon cancer by regulating the characteristics of CSCs. | * |
dc.language | English | * |
dc.publisher | MDPI AG | * |
dc.subject | Sasa quelpaertensis Nakai leaf extract | * |
dc.subject | colon cancer | * |
dc.subject | cancer stem cells | * |
dc.subject | self-renewal | * |
dc.subject | differentiation | * |
dc.title | Sasa quelpaertensis Leaf Extract Inhibits Colon Cancer by Regulating Cancer Cell Stemness in Vitro and in Vivo | * |
dc.type | Article | * |
dc.relation.issue | 5 | * |
dc.relation.volume | 16 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 9976 | * |
dc.relation.lastpage | 9997 | * |
dc.relation.journaltitle | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | * |
dc.identifier.doi | 10.3390/ijms16059976 | * |
dc.identifier.wosid | WOS:000356241400052 | * |
dc.identifier.scopusid | 2-s2.0-84929340108 | * |
dc.author.google | Min, Soo Jin | * |
dc.author.google | Lim, Ji Ye | * |
dc.author.google | Kim, Haeng Ran | * |
dc.author.google | Kim, Se-Jae | * |
dc.author.google | Kim, Yuri | * |
dc.contributor.scopusid | 김유리(37066214900;55581176400) | * |
dc.date.modifydate | 20240130115050 | * |