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A cohort study of incident microalbuminuria in relation to HOMA-IR in Korean men
- Title
- A cohort study of incident microalbuminuria in relation to HOMA-IR in Korean men
- Authors
- Park, Sung Keun; Chun, Hyejin; Ryoo, Jae-Hong; Lee, Sang Wha; Lee, Hong Soo; Shim, Kyung Won; Cho, Choo Yon; Ryu, Dorig-Ryeol; Ko, Taeg Su; Kim, Eugene; Park, Se-Jin; Park, Jai Hyung; Hong, Seok Jin; Hong, Hyun Pyo
- Ewha Authors
- 이상화; 이홍수; 심경원; 류동열; 전혜진
- SCOPUS Author ID
- 이상화

; 이홍수
; 심경원
; 류동열


; 전혜진
- Issue Date
- 2015
- Journal Title
- CLINICA CHIMICA ACTA
- ISSN
- 0009-8981
1873-3492
- Citation
- CLINICA CHIMICA ACTA vol. 446, pp. 111 - 116
- Keywords
- Insulin resistance; HOMA-IR; Microalbuminuria
- Publisher
- ELSEVIER SCIENCE BV
- Indexed
- SCI; SCIE; SCOPUS

- Document Type
- Article
- Abstract
- Background: Despite the previous studies showing the relationship between microalbuminuria and insulin resistance, longitudinal effect of insulin resistance on development of microalbuminuria is not clearly identified in non-diabetic population. Methods: One thousand six hundred three non-diabetic Korean men without microalbuminuria in 2005 had been followed up for the development of microalbuminuria until 2010. Microalbuminuria was evaluated by urine-albumin creatinine ration, and insulin resistance was evaluated by homeostasis model assessment of insulin resistance (HOMA-IR). Cox proportional hazards model was used to estimate the risk for microalbuminuria according to the tertile of HOMA-IR. Results: During 5465.8 person-y of average follow-up, microalbuminuria developed in 76 (4.7%) participants. Incidence of microalbuminuria increased in proportion to the level of HOMA-IR (tertile 1: 3.0%, tertile 2: 4.1%, tertile 3: 7.1%, P < 0.001). When the 1st tertile of HOMA-IR was set as reference, hazard ratios and 95% confidence interval were 1.15 (0.56-235) and 2.07 (1.05-4.09) for those in the 2nd and 3rd tertiles of HOMA-IR, even after adjusting multiple covariates, respectively (P for linear trend = 0.054). Conclusions: Increased insulin resistance was a predictor of microalbuminuria in Korean men. (C) 2015 Elsevier B.V. All rights reserved.
- DOI
- 10.1016/j.cca.2015.03.043
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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