Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 허규정 | * |
dc.contributor.author | 여창열 | * |
dc.date.accessioned | 2016-08-27T04:08:28Z | - |
dc.date.available | 2016-08-27T04:08:28Z | - |
dc.date.issued | 2015 | * |
dc.identifier.issn | 8756-3282 | * |
dc.identifier.issn | 1873-2763 | * |
dc.identifier.other | OAK-14890 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/217194 | - |
dc.description.abstract | E3 ubiquitin ligase Cbl-b and c-Cbl play important roles in bone formation and maintenance. Cbl-b and c-Cbl regulate the activity of various receptor tyrosine kinases and intracellular protein tyrosine kinases mainly by regulating the degradation of target proteins. However, the precise mechanisms of how Cbl-b and c-Cbl regulate osteoblast differentiation are not well known. In this study, we investigated potential targets of Cbl-b and c-Cbl. We found that Cbl-b and c-Cbl inhibit BMP2-induced osteoblast differentiation in mesenchymal cells. Among various osteogenic transcription factors, we identified that Cbl-b and c-Cbl suppress the protein stability and transcriptional activity of Osterix. Our results suggest that Cbl-b and c-Cbl inhibit the function of Osterix by enhancing the ubiquitin-proteasome-mediated degradation of Osterix. Taken together, we propose novel regulatory roles of Cbl-b and c-Cbl during osteoblast differentiation in which Cbl-b and c-Cbl regulate the degradation of Osterix through the ubiquitin-proteasome pathway. (C) 2015 Elsevier Inc. All rights reserved. | * |
dc.language | English | * |
dc.publisher | ELSEVIER SCIENCE INC | * |
dc.subject | Cbl | * |
dc.subject | Osterix | * |
dc.subject | Ubiquitination | * |
dc.subject | Osteoblast differentiation | * |
dc.title | Cbl-b and c-Cbl negatively regulate osteoblast differentiation by enhancing ubiquitination and degradation of Osterix | * |
dc.type | Article | * |
dc.relation.volume | 75 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 201 | * |
dc.relation.lastpage | 209 | * |
dc.relation.journaltitle | BONE | * |
dc.identifier.doi | 10.1016/j.bone.2015.02.026 | * |
dc.identifier.wosid | WOS:000353075100026 | * |
dc.author.google | Choi, You Hee | * |
dc.author.google | Han, Younho | * |
dc.author.google | Lee, Sung Ho | * |
dc.author.google | Jin, Yun-Hye | * |
dc.author.google | Bahn, Minjin | * |
dc.author.google | Hur, Kyu Chung | * |
dc.author.google | Yeo, Chang-Yeol | * |
dc.author.google | Lee, Kwang Youl | * |
dc.contributor.scopusid | 허규정(7005230301) | * |
dc.contributor.scopusid | 여창열(7102545519) | * |
dc.date.modifydate | 20240419142344 | * |