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Dendrimeric siRNA for Efficient Gene Silencing
- Title
- Dendrimeric siRNA for Efficient Gene Silencing
- Authors
- Hong, Cheol Am; Eltoukhy, Ahmed A.; Lee, Hyukjin; Langer, Robert; Anderson, Daniel G.; Nam, Yoon Sung
- Ewha Authors
- 이혁진
- SCOPUS Author ID
- 이혁진
- Issue Date
- 2015
- Journal Title
- ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- ISSN
- 1433-7851
1521-3773
- Citation
- ANGEWANDTE CHEMIE-INTERNATIONAL EDITION vol. 54, no. 23, pp. 6740 - 6744
- Keywords
- dendrimeric nanostructures; gene silencing; poly(-amino ester); polymeric condensation; siRNA
- Publisher
- WILEY-V C H VERLAG GMBH
- Indexed
- SCI; SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Programmable molecular self-assembly of siRNA molecules provides precisely controlled generation of dendrimeric siRNA nanostructures. The second-generation dendrimers of siRNA can be effectively complexed with a low-molecular-weight, cationic polymer (poly(-amino ester), PBAE) to generate stable nanostructures about 160nm in diameter via strong electrostatic interactions. Condensation and gene silencing efficiencies increase with the increased generation of siRNA dendrimers due to a high charge density and structural flexibility.
- DOI
- 10.1002/anie.201412493
- Appears in Collections:
- 약학대학 > 약학과 > Journal papers
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