Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 김승철 | - |
dc.date.accessioned | 2016-08-27T04:08:22Z | - |
dc.date.available | 2016-08-27T04:08:22Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 1741-427X | - |
dc.identifier.issn | 1741-4288 | - |
dc.identifier.other | OAK-14806 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/217138 | - |
dc.description.abstract | In traditional Chinese medicine, Persicaria chinensis L. has been prescribed to cure numerous inflammatory disorders. We previously analyzed the bioactivity of the methanol extract of this plant (Pc-ME) against LPS-induced NO and PGE(2) in RAW264.7 macrophages and found that it preventedHCl/EtOH-induced gastric ulcers in mice. The purpose of the current study was to explore the molecular mechanism by which Pc-ME inhibits activator protein-(AP-) 1 activation pathway and mediates its hepatoprotective activity. To investigate the putative therapeutic properties of Pc-ME against AP-1-mediated inflammation and hepatotoxicity, lipopolysaccharide-(LPS-) stimulated RAW264.7 and U937 cells, a monocyte-like human cell line, and an LPS/D-galactosamine(D-GalN-) induced acute hepatitis mouse model were employed. The expression of LPS-induced proinflammatory cytokines including interleukin-(IL-) 1 beta, IL-6, and tumor necrosis factor-alpha (TNF-alpha) was significantly diminished by Pc-ME. Moreover, Pc-ME reduced AP-1 activation and mitogen-activated protein kinase (MAPK) phosphorylation in both LPS-stimulated RAW264.7 cells and differentiated U937 cells. Additionally, we highlighted the hepatoprotective and curative effects of Pc-ME pretreated orally in a mouse model of LPS/D-GalN-intoxicated acute liver injury by demonstrating the significant reduction in elevated serum AST and ALT levels and histological damage. Therefore, these results strongly suggest that Pc-ME could function as an antihepatitis remedy suppressing MAPK/AP-1-mediated inflammatory events. | - |
dc.language | English | - |
dc.publisher | HINDAWI PUBLISHING CORPORATION | - |
dc.title | AP-1-Targeting Anti-Inflammatory Activity of the Methanolic Extract of Persicaria chinensis | - |
dc.type | Article | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.journaltitle | EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | - |
dc.identifier.doi | 10.1155/2015/608126 | - |
dc.identifier.wosid | WOS:000354764000001 | - |
dc.identifier.scopusid | 2-s2.0-84926676057 | - |
dc.author.google | Hossen, Muhammad Jahangir | - |
dc.author.google | Kim, Seung Cheol | - |
dc.author.google | Son, Young-Jin | - |
dc.author.google | Baek, Kwang-Soo | - |
dc.author.google | Kim, Eunji | - |
dc.author.google | Yang, Woo Seok | - |
dc.author.google | Jeong, Deok | - |
dc.author.google | Park, Jae Gwang | - |
dc.author.google | Kim, Han Gyung | - |
dc.author.google | Chung, Woo-Jae | - |
dc.author.google | Yoon, Keejung | - |
dc.author.google | Ryou, Chongsuk | - |
dc.author.google | Lee, Sang Yeol | - |
dc.author.google | Kim, Jong-Hoon | - |
dc.author.google | Cho, Jae Youl | - |
dc.contributor.scopusid | 김승철(35264000100) | - |
dc.date.modifydate | 20230210135401 | - |