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Glycogen synthase kinase 3 beta ubiquitination by TRAF6 regulates TLR3-mediated pro-inflammatory cytokine production

Title
Glycogen synthase kinase 3 beta ubiquitination by TRAF6 regulates TLR3-mediated pro-inflammatory cytokine production
Authors
Ko, RyeojinPark, Jin HeeHa, HyunilChoi, YongwonLee, Soo Young
Ewha Authors
이수영
SCOPUS Author ID
이수영scopusscopus
Issue Date
2015
Journal Title
NATURE COMMUNICATIONS
ISSN
2041-1723JCR Link
Citation
NATURE COMMUNICATIONS vol. 6
Publisher
NATURE PUBLISHING GROUP
Indexed
SCI; SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
TRAF6 is critical for the production of inflammatory cytokines in various TLR-mediated signalling pathways. However, it is poorly understood how TRAF6 regulates TLR3 responses. Here we demonstrate that GSK3 beta interacts with TRAF6 and positively regulates the TLR3-mediated signalling. Suppression of GSK3 beta expression or its kinase activity drastically reduces the production of inflammatory cytokines and the induction of c-Fos by decreasing ERK and p38 phosphorylation. GSK3 beta physically associates with TRAF6 in a TLR3 ligand poly I:C-dependent manner. TRAF6 is determined to be a direct E3 ligase for GSK3 beta, and TRAF6-mediated GSK3 beta ubiquitination is essential for poly I:C-dependent cytokine production by promoting the TLR3 adaptor protein TRIF-assembled signalling complex.
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DOI
10.1038/ncomms7765
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자연과학대학 > 생명과학전공 > Journal papers
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