Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 서은경 | * |
dc.contributor.author | 한아름 | * |
dc.date.accessioned | 2016-08-27T04:08:16Z | - |
dc.date.available | 2016-08-27T04:08:16Z | - |
dc.date.issued | 2015 | * |
dc.identifier.issn | 1612-1872 | * |
dc.identifier.issn | 1612-1880 | * |
dc.identifier.other | OAK-14670 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/217074 | - |
dc.description.abstract | Coicis semen (=the hulled seed of Coix lacryma-jobi L. var. ma-yuen (Rom.Caill.) Stapf; Gramineae), commonly known as adlay and Job's tears, is widely used in traditional medicine and as a nutritious food. Bioassay-guided fractionation of the AcOEt fraction of unhulled adlays, using measurement of nitric oxide (NO) production on lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cells, led to the isolation and identification of two new stereoisomers, (+)-(7S,8R,7S,8R)-guaiacylglycerol -O-4-dihydrodisinapyl ether (1) and (+)-(7S,8R,7R,8R)-guaiacylglycerol -O-4-dihydrodisinapyl ether (2), together with six known compounds, 3-8. Compounds 3 and 4 exhibited inhibitory activities on LPS-induced NO production with IC50 values of 1.4 and 3.7M, respectively, and suppressed inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) protein expressions in RAW 264.7 macrophage cells. Simple high-performance liquid chromatography with ultraviolet detection (HPLC/UV) was used to compare the AcOEt fraction of unhulled adlays responsible for the anti-inflammatory activity in RAW 264.7 cells and the inactive AcOEt fraction of hulled adlays. | * |
dc.language | English | * |
dc.publisher | WILEY-V C H VERLAG GMBH | * |
dc.subject | Coix lacryma-jobi | * |
dc.subject | Phenolic compounds | * |
dc.subject | Inducible nitric oxide synthase (iNOS) | * |
dc.subject | Cyclooxygenase-2 (COX-2) | * |
dc.title | A Comparative Study on Hulled Adlay and Unhulled Adlay through Evaluation of Their LPS-Induced Anti-Inflammatory Effects, and Isolation of Pure Compounds | * |
dc.type | Article | * |
dc.relation.issue | 3 | * |
dc.relation.volume | 12 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 380 | * |
dc.relation.lastpage | 387 | * |
dc.relation.journaltitle | CHEMISTRY & BIODIVERSITY | * |
dc.identifier.doi | 10.1002/cbdv.201400242 | * |
dc.identifier.wosid | WOS:000351316100005 | * |
dc.identifier.scopusid | 2-s2.0-84924530537 | * |
dc.author.google | Choi, Goeun | * |
dc.author.google | Han, Ah-Reum | * |
dc.author.google | Lee, Joo Hee | * |
dc.author.google | Park, Ji-Youn | * |
dc.author.google | Kang, Unwoo | * |
dc.author.google | Hong, Jongki | * |
dc.author.google | Kim, Yeong Shik | * |
dc.author.google | Seo, Eun-Kyoung | * |
dc.contributor.scopusid | 서은경(7005953758) | * |
dc.contributor.scopusid | 한아름(56278315000;34769874800) | * |
dc.date.modifydate | 20240130112016 | * |