Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 유경하 | * |
dc.contributor.author | 정병문 | * |
dc.contributor.author | 우소연 | * |
dc.contributor.author | 김한수 | * |
dc.contributor.author | 정성철 | * |
dc.contributor.author | 이혜진 | * |
dc.contributor.author | 조인호 | * |
dc.contributor.author | 박윤신 | * |
dc.contributor.author | 박주원 | * |
dc.contributor.author | 이혁진 | * |
dc.contributor.author | 유연실 | * |
dc.contributor.author | 김유희 | * |
dc.date.accessioned | 2016-08-27T04:08:14Z | - |
dc.date.available | 2016-08-27T04:08:14Z | - |
dc.date.issued | 2015 | * |
dc.identifier.issn | 2045-2322 | * |
dc.identifier.other | OAK-14629 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/217046 | - |
dc.description.abstract | Liver transplantation is the treatment of choice for chronic liver failure, although it is complicated by donor shortage, surgery-related complications, and immunological rejection. Cell transplantation is an alternative, minimally invasive treatment option with potentially fewer complications. We used human palatine tonsil as a novel source of mesenchymal stem cells (T-MSCs) and examined their ability to differentiate into hepatocyte-like cells in vivo and in vitro. Carbon tetrachloride (CCl4) mouse model was used to investigate the ability of T-MSCs to home to the site of liver injury. T-MSCs were only detected in the damaged liver, suggesting that they are disease-responsive. Differentiation of T-MSCs into hepatocyte-like cells was confirmed in vitro as determined by expression of hepatocyte markers. Next, we showed resolution of liver fibrosis by T-MSCs via reduction of TGF-beta expression and collagen deposition in the liver. We hypothesized that autophagy activation was a possible mechanism for T-MSC-mediated liver recovery. In this report, we demonstrate for the first time that T-MSCs can differentiate into hepatocyte-like cells and ameliorate liver fibrosis via autophagy activation and down-regulation of TGF-beta. These findings suggest that T-MSCs could be used as a novel source for stem cell therapy targeting liver diseases. | * |
dc.language | English | * |
dc.publisher | NATURE PUBLISHING GROUP | * |
dc.title | Tonsil-derived Mesenchymal Stem Cells Ameliorate CCl4-induced Liver Fibrosis in Mice via Autophagy Activation | * |
dc.type | Article | * |
dc.relation.volume | 5 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | SCIENTIFIC REPORTS | * |
dc.identifier.doi | 10.1038/srep08616 | * |
dc.identifier.wosid | WOS:000350294200006 | * |
dc.author.google | Park, Minhwa | * |
dc.author.google | Kim, Yu-Hee | * |
dc.author.google | Woo, So-Youn | * |
dc.author.google | Lee, Hye Jin | * |
dc.author.google | Yu, Yeonsil | * |
dc.author.google | Kim, Han Su | * |
dc.author.google | Park, Yoon Shin | * |
dc.author.google | Jo, Inho | * |
dc.author.google | Park, Joo-Won | * |
dc.author.google | Jung, Sung-Chul | * |
dc.author.google | Lee, Hyukjin | * |
dc.author.google | Jeong, Byeongmoon | * |
dc.author.google | Ryu, Kyung-Ha | * |
dc.contributor.scopusid | 유경하(14038236200) | * |
dc.contributor.scopusid | 정병문(7102237959) | * |
dc.contributor.scopusid | 우소연(7402853365) | * |
dc.contributor.scopusid | 김한수(56509934900) | * |
dc.contributor.scopusid | 정성철(57008539100) | * |
dc.contributor.scopusid | 이혜진(56192810300) | * |
dc.contributor.scopusid | 조인호(26643129000;56663841900) | * |
dc.contributor.scopusid | 박윤신(35975370400) | * |
dc.contributor.scopusid | 박주원(8656832200) | * |
dc.contributor.scopusid | 이혁진(55233457200) | * |
dc.contributor.scopusid | 유연실(56329449400) | * |
dc.contributor.scopusid | 김유희(15764983100) | * |
dc.date.modifydate | 20240422114059 | * |