Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박혜영 | - |
dc.date.accessioned | 2016-08-27T04:08:13Z | - |
dc.date.available | 2016-08-27T04:08:13Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0968-0896 | - |
dc.identifier.issn | 1464-3391 | - |
dc.identifier.other | OAK-14611 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/217036 | - |
dc.description.abstract | A novel series of 4-nitroindole sulfonamides containing a methyleneamino-N,N-dimethylformamidine were prepared. The binding of these compounds to 5-HT2A and 5-HT2C was evaluated, and most of the compounds showed IC50 values of less than 1 mu M, and exhibited high selectivity for the 5-HT2C receptor. However, little selectivity was observed in the functional assay for 5-HT6 receptors. The computational modeling studies further validated the biological results and also demonstrated a reasonable correlation between the activity of compounds and the mode of superimposition with specified pharmacophoric features. (C) 2015 Elsevier Ltd. All rights reserved. | - |
dc.language | English | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.subject | 4-Nitroindole | - |
dc.subject | Sulfonamides | - |
dc.subject | Methyleneamino-N,N-dimethylformamidine group | - |
dc.subject | 5-HT2A | - |
dc.subject | 5-HT2C | - |
dc.subject | 5-HT6 receptor | - |
dc.title | Synthesis and biological evaluation of 4-nitroindole derivatives as 5-HT2A receptor antagonists | - |
dc.type | Article | - |
dc.relation.issue | 6 | - |
dc.relation.volume | 23 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 1313 | - |
dc.relation.lastpage | 1320 | - |
dc.relation.journaltitle | BIOORGANIC & MEDICINAL CHEMISTRY | - |
dc.identifier.doi | 10.1016/j.bmc.2015.01.032 | - |
dc.identifier.wosid | WOS:000349967600010 | - |
dc.identifier.scopusid | 2-s2.0-84923534690 | - |
dc.author.google | Hayat, Faisal | - |
dc.author.google | Viswanath, Ambily Nath Indu | - |
dc.author.google | Pae, Ae Nim | - |
dc.author.google | Rhim, Hyewhon | - |
dc.author.google | Park, Woo-Kyu | - |
dc.author.google | Choo, Hea-Young Park | - |
dc.contributor.scopusid | 박혜영(34972649500;57200273796) | - |
dc.date.modifydate | 20230411110509 | - |