Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 김주영 | - |
dc.date.accessioned | 2016-08-27T04:08:11Z | - |
dc.date.available | 2016-08-27T04:08:11Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.other | OAK-14590 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/217019 | - |
dc.description.abstract | Obesity is a known risk factor for allergic asthma. It has been recognized as a key player in the pathogenesis of several inflammatory disorders via activation of macrophages, which is also vital to the development of allergic asthma. We investigated the mechanism of obesity-related asthma and whether treating obesity through exercise or diet ameliorates the severity of asthma in the obesity-related asthma model. We generated diet-induced obesity (DIO) in C57BL/6 mice by high-fat-feeding and ovalbumin-induced asthma (lean-OVA or DIOOVA). The DIO-OVA mice were then treated with tumor necrosis factor (TNF)-alpha neutralizing antibody as a TNF-alpha blockade or a Cl2MDP-containing liposome to induce an alveolar macrophage deficiency. To treat obesity, the DIO-OVA mice were under dietary restrictions or exercised. The pathophysiological and immunological responses were analyzed. Airway hyperresponsiveness (AHR), serum IgE and TNF-alpha levels in the lung tissue increased in the DIO-OVA mice compared to the lean-OVA mice. Both the TNF-alpha blockade and depletion of alveolar macrophages in the DIO-OVA mice decreased AHR compared to the DIOOVA mice. Treating obesity by exercise or through dietary means also reduced pulmonary TNF-alpha levels and AHR in the DIO-OVA mice. These results suggest that restoring normal body weight is an appropriate strategy for reducing TNF-alpha levels, and controlling inflammation may help improve asthma severity and control in obesity-related asthma. | - |
dc.language | English | - |
dc.publisher | PUBLIC LIBRARY SCIENCE | - |
dc.title | Obesity Increases Airway Hyperresponsiveness via the TNF-alpha Pathway and Treating Obesity Induces Recovery | - |
dc.type | Article | - |
dc.relation.issue | 2 | - |
dc.relation.volume | 10 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.journaltitle | PLOS ONE | - |
dc.identifier.doi | 10.1371/journal.pone.0116540 | - |
dc.identifier.wosid | WOS:000349444900047 | - |
dc.author.google | Kim, Joo Young | - |
dc.author.google | Sohn, Jung-Ho | - |
dc.author.google | Lee, Jae-Hyun | - |
dc.author.google | Park, Jung-Won | - |
dc.contributor.scopusid | 김주영(36152545300;57221537444) | - |
dc.date.modifydate | 20230118111324 | - |