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Mohangamides A and B, New Dilactone-Tethered Pseudo-Dimeric Peptides Inhibiting Candida albicans Isocitrate Lyase
- Title
- Mohangamides A and B, New Dilactone-Tethered Pseudo-Dimeric Peptides Inhibiting Candida albicans Isocitrate Lyase
- Authors
- Bae, Munhyung; Kim, Heegyu; Moon, Kyuho; Nam, Sang-Jip; Shin, Jongheon; Oh, Ki-Bong; Oh, Dong-Chan
- Ewha Authors
- 남상집
- SCOPUS Author ID
- 남상집
- Issue Date
- 2015
- Journal Title
- ORGANIC LETTERS
- ISSN
- 1523-7060
1523-7052
- Citation
- ORGANIC LETTERS vol. 17, no. 3, pp. 712 - 715
- Publisher
- AMER CHEMICAL SOC
- Indexed
- SCI; SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Mohangamides A and B (1-2) were discovered from a marine Streptomyces sp. collected in an intertidal mud flat. The structures of the compounds were elucidated as novel dilactone-tethered pseudodimeric peptides bearing two unusual acyl chains and 14 amino acid residues based on comprehensive spectroscopic analysis. The absolute configurations of the mohangamides were determined by chemical derivatizations, followed by chromatographic and spectroscopic analyses. Mohangamide A displayed strong inhibitory activity against Candida albicans isocitrate lyase.
- DOI
- 10.1021/ol5037248
- Appears in Collections:
- 자연과학대학 > 화학·나노과학전공 > Journal papers
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