Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 김유리 | * |
dc.date.accessioned | 2016-08-27T04:08:09Z | - |
dc.date.available | 2016-08-27T04:08:09Z | - |
dc.date.issued | 2015 | * |
dc.identifier.issn | 1976-1457 | * |
dc.identifier.issn | 2005-6168 | * |
dc.identifier.other | OAK-12421 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/216998 | - |
dc.description.abstract | BACKGROUND/OBJECTIVES: Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, involves chronic inflammation of the gastrointestinal tract. Previously, Sasa quelpaertensis leaves have been shown to mediate anti-inflammation and anti-cancer effects, although it remains unclear whether Sasa leaves are able to attenuate inflammation-related intestinal diseases. Therefore, the aim of this study was to investigate the anti-inflammatory effects of Sasa quelpaertensis leaf extract (SQE) using an in vitro co-culture model of the intestinal epithelial environment. MATERIALS/METHODS: An in vitro co-culture system was established that consisted of intestinal epithelial Caco-2 cells and RAW 264.7 macrophages. Treatment with lipopolysaccharide (LPS) was used to induce inflammation. RESULTS: Treatment with SQE significantly suppressed the secretion of LPS-induced nitric oxide (NO), prostaglandin E2 (PGE(2)), IL-6, and IL-1 beta in co-cultured RAW 264.7 macrophages. In addition, expressions of inducible nitric oxide synthase (iNOS), cyclooxygenase (COX)-2, and tumor necrosis factor (TNF)-alpha were down-regulated in response to inhibition of I kappa B alpha phosphorylation by SQE. Compared with two bioactive compounds that have previously been identified in SQE, tricin and P-coumaric acid, SQE exhibited the most effective anti-inflammatory properties. CONCLUSIONS: SQE exhibited intestinal anti-inflammatory activity by inhibiting various inflammatory mediators mediated through nuclear transcription factor kappa-B (NF-kappa B) activation. Thus, SQE has the potential to ameliorate inflammation-related diseases, including IBD, by limiting excessive production of pro-inflammatory mediators. | * |
dc.language | English | * |
dc.publisher | KOREAN NUTRITION SOC | * |
dc.subject | Sasa quelpaertensis | * |
dc.subject | co-culture model | * |
dc.subject | anti-inflammation | * |
dc.subject | pro-inflammatory mediators | * |
dc.title | Intestinal anti-inflammatory activity of Sasa quelpaertensis leaf extract by suppressing lipopolysaccharide-stimulated inflammatory mediators in intestinal epithelial Caco-2 cells co-cultured with RAW 264.7 macrophage cells | * |
dc.type | Article | * |
dc.relation.issue | 1 | * |
dc.relation.volume | 9 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 3 | * |
dc.relation.lastpage | 10 | * |
dc.relation.journaltitle | NUTRITION RESEARCH AND PRACTICE | * |
dc.identifier.doi | 10.4162/nrp.2015.9.1.3 | * |
dc.identifier.wosid | WOS:000348884100001 | * |
dc.author.google | Kim, Kyung-Mi | * |
dc.author.google | Kim, Yoo-Sun | * |
dc.author.google | Lim, Ji Ye | * |
dc.author.google | Min, Soo Jin | * |
dc.author.google | Ko, Hee-Chul | * |
dc.author.google | Kinn, Se-Jae | * |
dc.author.google | Kim, Yuri | * |
dc.contributor.scopusid | 김유리(37066214900;55581176400) | * |
dc.date.modifydate | 20240130115050 | * |