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The burden of nosocomial staphylococcus aureus bloodstream infection in South Korea: a prospective hospital-based nationwide study

Title
The burden of nosocomial staphylococcus aureus bloodstream infection in South Korea: a prospective hospital-based nationwide study
Authors
Kim, Chung-JongKim, Hong-BinOh, Myoung-donKim, YunheeKim, ArimOh, Sung-HeeSong, Kyoung-HoKim, Eu SukCho, Yong KyunChoi, Young HwaPark, JinyongKim, Baek-NamKim, Nam-JoongKim, Kye-HyungLee, Eun JungJun, Jae-BumKim, Young KeunKiem, Sung MinChoi, Hee JungChoo, Eun JuSohn, Kyung-mokLee, ShinwonChang, Hyun HaBang, Ji HwanLee, Su JinLee, Jae HoonPark, Seong YeonJeon, Min HyokYun, Na Ra|KIND Study GrpKorea Infect Dis Study Grp
Ewha Authors
최희정
SCOPUS Author ID
최희정scopus
Issue Date
2014
Journal Title
BMC INFECTIOUS DISEASES
ISSN
1471-2334JCR Link
Citation
BMC INFECTIOUS DISEASES vol. 14
Keywords
Staphylococcus aureusBacteremiaIncidenceHospital infections
Publisher
BIOMED CENTRAL LTD
Indexed
SCIE; SCOPUS WOS
Document Type
Article
Abstract
Background: We estimated the nationwide burden of nosocomial S. aureus bloodstream infection (SA-BSI), a major cause of nosocomial infection, in South Korea. Methods: To evaluate the nationwide incidence of nosocomial SA-BSI, cases of SA-BSI were prospectively collected from 22 hospitals with over 500 beds over 4 months. Data on patient-days were obtained from a national health insurance database containing the claims data for all healthcare facilities in South Korea. The additional cost of SA-BSI was estimated through a matched case-control study. The economic burden was calculated from the sum of the medical costs, the costs of caregiving and loss of productivity. Results: Three hundred and thirty nine cases of nosocomial SA-BSI were included in the study: 254 cases of methicillin-resistant SA-BSI (MRSA-BSI) and 85 cases of methicillin-susceptible SA-BSI (MSSA-BSI). Death related to BSI occurred in 81 cases (31.9%) of MRSA-BSI and 12 cases (14.1%) of MSSA-BSI. The estimated incidence of nosocomial MRSA-BSI was 0.12/1,000 patient-days and that of nosocomial MSSA-BSI, 0.04/1,000 patient-days. The estimated annual cases of nosocomial BSI were 2,946 for MRSA and 986 for MSSA in South Korea. The additional economic burden per case of nosocomial SA-BSI was US $20,494 for MRSA-BSI and $6,914 for MSSA-BSI. Total additional annual cost of nosocomial SA-BSI was $67,192,559. Conclusion: In view of the burden of nosocomial SA-BSI, a national strategy for reducing nosocomial SA-BSI is urgently needed in South Korea.
DOI
10.1186/s12879-014-0590-4
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의과대학 > 의학과 > Journal papers
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