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dc.contributor.author임재향*
dc.date.accessioned2016-08-27T04:08:04Z-
dc.date.available2016-08-27T04:08:04Z-
dc.date.issued2014*
dc.identifier.issn0001-6489*
dc.identifier.issn1651-2251*
dc.identifier.otherOAK-12154*
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/216952-
dc.description.abstractConclusion: Bullae of type 1 plasminogen activator inhibitor (PAI-1) knockout (KO) mice showed low levels of inflammation against nontypable Haemophilus influenzae (NTHi) at the early stage of otitis media (OM). However, PAI-1 KO mice fail to terminate inflammation, which may significantly contribute to the development of tympanosclerosis in PAI-1 KO mice. Objective: To investigate the role of PAI-1 in the pathogenesis of OM and subsequent tympanosclerosis. Methods: OM was induced with NTHi in PAI-1 KO and background control C57BL/6 mice. mRNA expression of PAI-1, tissue-type plasminogen activator (tPA), and urokinase-type plasminogen activator (uPA) was measured in the bullae of C57BL/6 mice. mRNA expression of interleukin (IL)-1 beta, tumor necrosis factor (TNF) alpha, macrophage inflammatory protein (MIP-2), tPA, and uPA in PAI-1 KO and C57BL/6 mice was compared. Histological changes produced by OM were compared at 1, 3, and 7 days after NTHi inoculation. Results: NTHi up-regulated the expression of PAI-1 and tPA in the bullae of C57BL/6 mice, but not uPA. mRNA expression of IL-1 beta, TNF alpha, and MIP-2 was low in PAI-1 KO mice at early time points, but significantly higher at the later stage of OM. Similarly to the gene expression results, histological changes associated with OM were less at days 1 and 3 in PAI-1 KO mice. However, unlike the gradual resolution of OM pathologies in C57BL/6 mice, PAI-1 KO mice showed significant pathological changes of tympanosclerosis.*
dc.languageEnglish*
dc.publisherINFORMA HEALTHCARE*
dc.subjectNontypable Haemophilus influenzae*
dc.subjecttype 1 plasminogen activator inhibitor*
dc.subjectinflammation*
dc.titlePAI-1 inhibits development of chronic otitis media and tympanosclerosis in a mouse model of otitis media*
dc.typeArticle*
dc.relation.issue12*
dc.relation.volume134*
dc.relation.indexSCI*
dc.relation.indexSCIE*
dc.relation.indexSCOPUS*
dc.relation.startpage1231*
dc.relation.lastpage1238*
dc.relation.journaltitleACTA OTO-LARYNGOLOGICA*
dc.identifier.doi10.3109/00016489.2014.940554*
dc.identifier.wosidWOS:000345214100004*
dc.author.googleShin, Seul Gi*
dc.author.googleKoh, Seo Hyun*
dc.author.googleWoo, Chang-Hoon*
dc.author.googleLim, Jae Hyang*
dc.contributor.scopusid임재향(7403454262)*
dc.date.modifydate20240429115530*
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의과대학 > 의학과 > Journal papers
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