Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 유연실 | - |
dc.date.accessioned | 2016-08-27T04:08:54Z | - |
dc.date.available | 2016-08-27T04:08:54Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0916-8451 | - |
dc.identifier.issn | 1347-6947 | - |
dc.identifier.other | OAK-11718 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/216875 | - |
dc.description.abstract | Allergic disease is dominated by Th2 immune responses. Interleukin (IL)-4 and IL-13, representative Th2 cytokines, play pivotal roles in the pathogenic activation of the Th2 immune response. In this study, we found that cyanidin-3-glucoside chloride (C3G), an anthocyanin suppressed IL-4 and IL-13 produced in activated EL-4 T cells but not Th1 cytokines including IL-2, interferon-gamma, or IL-12. IL-4 and IL-13 mRNA levels and luciferase activation in cells transiently transfected with IL-4 and IL-13 promoter reporter plasmids were significantly inhibited by C3G, suggesting that suppression might be, at least in part, regulated at the transcriptional level. Data from western blot and reverse transcription-polymerase chain reaction analyses of transcription factors involved in cytokine expression suggested that expression of GATA-3, but not T-bet, was downregulated in the nucleus by C3G. Taken together, our data indicate that C3G may has potential as an anti-allergic agent suppressing Th2 activation by downregulating Th2 cytokines and the GATA3 transcription factor in allergies. | - |
dc.language | English | - |
dc.publisher | TAYLOR & | - |
dc.publisher | FRANCIS LTD | - |
dc.subject | interleukin-4 (IL-4) | - |
dc.subject | interleukin-13 (IL-13) | - |
dc.subject | cyaniding-3-glucoside (C3G) C3G | - |
dc.subject | GATA-binding protein 3 (GATA-3) | - |
dc.subject | anti-allergic agent | - |
dc.title | Cyanidin-3-glucoside suppresses Th2 cytokines and GATA-3 transcription factor in EL-4 T cells | - |
dc.type | Article | - |
dc.relation.issue | 6 | - |
dc.relation.volume | 78 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 1037 | - |
dc.relation.lastpage | 1043 | - |
dc.relation.journaltitle | BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | - |
dc.identifier.doi | 10.1080/09168451.2014.912115 | - |
dc.identifier.wosid | WOS:000340133800019 | - |
dc.author.google | Pyo, Myoung Yun | - |
dc.author.google | Yoon, Soo Jeong | - |
dc.author.google | Yu, Yeonsil | - |
dc.author.google | Park, Sunyoung | - |
dc.author.google | Jin, Mirim | - |
dc.contributor.scopusid | 유연실(56329449400) | - |
dc.date.modifydate | 20230411101830 | - |