Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 유경하 | * |
dc.contributor.author | 이현국 | * |
dc.contributor.author | 민석기 | * |
dc.date.accessioned | 2016-08-27T04:08:50Z | - |
dc.date.available | 2016-08-27T04:08:50Z | - |
dc.date.issued | 2014 | * |
dc.identifier.issn | 0172-6390 | * |
dc.identifier.other | OAK-11329 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/216836 | - |
dc.description.abstract | Background/Aims: The plasticity of bone marrow stem cells has been confirmed to self-renew and transdifferentiate into hepatocytes. Thus, we performed autologous stem cell transplantation for rapid liver regeneration with extensive hepatectomy in hepatocellular cancer patients. Methodology: With in formed consent, patients aged 20 to 75 who needed large extensive hepatectomy due to hepatocellular carcinoma were randomly divided into three groups: control, mononuclear cells (MNCs), and CD34+ cells, based on infused cell type. After portal vein embolization (PVE), mobilized MNCs or CD34+ cells were returned to the patient via the portal vein on mobilization day without manipulation. Liver volume, liver function, Clinical score and Indocyanine green R15 (ICG-R15) were compared before and after PVE. Results: Total bilirubin, albumin, and clinical score showed significant improvement (p < 0.05) 1 week post-infusion, with no significant difference between MNC and CD34+ cell groups. Four patients (control, 1; MNC, 1; CD34+, 2) started at over 18% ICG-R15 but can be overturned after PVE. Daily hepatic volume growth (mL/day) was 2.5 for MNC and 4.9 for CD34+ groups, resulting in significant increase over controls (1.1; p < 0.05). We found no correlation between the number of applied CD34+ cells and daily gains in left lateral lobe volume. Conclusions: Improvements in liver volume, liver function, clinical score and ICG-R15 suggest that autologous stem cell transplantation is a promising method for liver regeneration. | * |
dc.language | English | * |
dc.publisher | H G E UPDATE MEDICAL PUBLISHING S A | * |
dc.subject | Autologous stem cell transplantation | * |
dc.subject | Liver volume | * |
dc.subject | Extensive hepatectomy | * |
dc.subject | Regeneration | * |
dc.subject | Stem cell | * |
dc.title | Autologous Stem Cell Transplantation for Expansion of Remnant Liver Volume with Extensive Hepatectomy | * |
dc.type | Article | * |
dc.relation.issue | 129 | * |
dc.relation.volume | 61 | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 156 | * |
dc.relation.lastpage | 161 | * |
dc.relation.journaltitle | HEPATO-GASTROENTEROLOGY | * |
dc.identifier.doi | 10.5754/hge13178 | * |
dc.identifier.wosid | WOS:000335085200032 | * |
dc.author.google | Han, Ho-Seong | * |
dc.author.google | Ahn, Keun Soo | * |
dc.author.google | Cho, Jai Young | * |
dc.author.google | Yoon, Yoo-Seok | * |
dc.author.google | Yoon, Chang Jin | * |
dc.author.google | Park, Kyoung Un | * |
dc.author.google | Min, Seog Ki | * |
dc.author.google | Lee, Hyeon Kook | * |
dc.author.google | Ryu, Kyung-Ha | * |
dc.contributor.scopusid | 유경하(14038236200) | * |
dc.contributor.scopusid | 이현국(8861888600) | * |
dc.contributor.scopusid | 민석기(8938656500) | * |
dc.date.modifydate | 20240419142421 | * |