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ANCA-Negative Wegener's Granulomatosis with Multiple Lower Cranial Nerve Palsies
- Title
- ANCA-Negative Wegener's Granulomatosis with Multiple Lower Cranial Nerve Palsies
- Authors
- Kim, Sung-Hee; Park, Jin; Bae, Jung Ho; Cho, Min-Sun; Park, Kee Duk; Jeong, Jee Hyang
- Ewha Authors
- 박기덕; 조민선; 배정호; 정지향
- SCOPUS Author ID
- 박기덕; 조민선; 배정호; 정지향
- Issue Date
- 2013
- Journal Title
- JOURNAL OF KOREAN MEDICAL SCIENCE
- ISSN
- 1011-8934
- Citation
- JOURNAL OF KOREAN MEDICAL SCIENCE vol. 28, no. 11, pp. 1690 - 1696
- Keywords
- Wegener Granulomatosis; Cranial Nerve Diseases; Refractory Sinusitis; c-ANCA Negative
- Publisher
- KOREAN ACAD MEDICAL SCIENCES
- Indexed
- SCI; SCIE; SCOPUS; KCI
- Document Type
- Article
- Abstract
- Wegener's granulomatosis (WG) is a systemic vasculitis affecting small and medium-sized vessels with granulomatous formation. Though it is known for respiratory tract and kidney involvement, neurologic manifestation has been also reported. Herein we report a patient who suffered pansinusitis with multiple lower cranial nerve palsies but reached remission by immunosuppressant after the diagnosis of WG. A 54-yr-old female visited with headache, hearing difficulty, and progressive bulbar symptoms. She experienced endoscopic sinus surgeries due to refractory sinusitis. Neurologic examination revealed multiple lower cranial nerve palsies. Vasculitic markers showed no abnormality. Nasal biopsy revealed granulomatous inflammation and vasculitis involving small vessels. Given cyclophosphamide and prednisolone, her symptoms were prominently improved. WG should be considered in the patient with multiple cranial nerve palsies, especially those with paranasal sinus disease. Because WG can be lethal if delayed in treatment, prompt immunosuppressant is warranted after the diagnostic tissue biopsy.
- DOI
- 10.3346/jkms.2013.28.11.1690
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
- Files in This Item:
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