Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 오세관 | * |
dc.contributor.author | 정재철 | * |
dc.date.accessioned | 2016-08-27T02:08:12Z | - |
dc.date.available | 2016-08-27T02:08:12Z | - |
dc.date.issued | 2010 | * |
dc.identifier.issn | 0253-4134 | * |
dc.identifier.other | OAK-7114 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/216489 | - |
dc.description.abstract | Simple synthesis and biological properties of flocoumafen 1 and its structural isomers are described. The key synthetic strategies involve Knoevenagel condensation, Grignard reaction, intramolecular ring cyclization and coupling reaction. Flocoumafen 1 was easily separated into cis and trans forms using flash column chromatography. They were then evaluated for suppression of LPS-induced NO generation and anti-excitotoxicity in vitro. It was found that the trans-flocoumafen was potent suppressor of NO generation with the concentration of 10 A mu M in vitro, while no significant effect for neurotoxicity in cultured cortical neurons. | * |
dc.language | English | * |
dc.publisher | INDIAN ACAD SCIENCES | * |
dc.subject | Flocoumafen | * |
dc.subject | intramolecular ring cyclization | * |
dc.subject | coupling reaction | * |
dc.subject | NO-generation | * |
dc.subject | neurotoxicity | * |
dc.title | Simple synthesis and biological evaluation of flocoumafen and its structural isomers | * |
dc.type | Article | * |
dc.relation.issue | 6 | * |
dc.relation.volume | 122 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 833 | * |
dc.relation.lastpage | 838 | * |
dc.relation.journaltitle | JOURNAL OF CHEMICAL SCIENCES | * |
dc.identifier.doi | 10.1007/s12039-010-0071-2 | * |
dc.identifier.wosid | WOS:000285097800006 | * |
dc.identifier.scopusid | 2-s2.0-78650113585 | * |
dc.author.google | Jung, Jae-Chul | * |
dc.author.google | Jang, Soyong | * |
dc.author.google | Oh, Seikwan | * |
dc.author.google | Park, Oee-Sook | * |
dc.contributor.scopusid | 오세관(7404103757) | * |
dc.contributor.scopusid | 정재철(7402897187) | * |
dc.date.modifydate | 20240123112233 | * |