Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김양하 | * |
dc.date.accessioned | 2016-08-27T02:08:08Z | - |
dc.date.available | 2016-08-27T02:08:08Z | - |
dc.date.issued | 2010 | * |
dc.identifier.issn | 1976-1457 | * |
dc.identifier.other | OAK-6698 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/216449 | - |
dc.description.abstract | There is an increasing interest in curcumin (Curcurna longa L.) as a cardiovascular disease (CVD) protective agent via decreased blood total cholesterol and low-density lipoprotein-cholesterol (LDL-cholesterol) level. The aim of this study was to investigate further the potential mechanism in the hypocholesterolemic effect of curcumin by measuring cholesterol 7a-hydroxylase (CYP7A1), a rate limiting enzyme in the biosynthesis of bile acid from cholesterol, at the mRNA level. Male Sprague-Dawley rats were fed a 45% high fat diet or same diet supplemented with curcumin (0.1% wt/wt) for 8 weeks. The curcumin diet significantly decreased serum triglyceride (TG) by 27%, total cholesterol (TC) by 33.8%, and LDL-cholesterol by 56%, respectively as compared to control group. The curcumin-supplemented diet also significantly lowered the atherogenic index (AI) by 48% as compared to control group. Hepatic TG level was significantly reduced by 41% in rats fed with curcumin-supplemented diet in comparison with control group (P < 0.05). Conversely, the curcumin diet significantly increased fecal TG and TC. The curcumin diet up-regulated hepatic CYP7A1 mRNA level by 2.16-fold, compared to control group p (P < 0.05). These findings suggested that the increases in the CYP7A1 gene expression may partially account for the hypocholesterolemic effect of curcumin. | * |
dc.language | English | * |
dc.publisher | KOREAN NUTRITION SOC | * |
dc.subject | Curcumin | * |
dc.subject | cholesterol | * |
dc.subject | CYP7A1 | * |
dc.subject | mRNA | * |
dc.subject | rat | * |
dc.title | Hypocholesterolemic effects of curcumin via up-regulation of cholesterol 7a-hydroxylase in rats fed a high fat diet | * |
dc.type | Article | * |
dc.relation.issue | 3 | * |
dc.relation.volume | 4 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 191 | * |
dc.relation.lastpage | 195 | * |
dc.relation.journaltitle | NUTRITION RESEARCH AND PRACTICE | * |
dc.identifier.doi | 10.4162/nrp.2010.4.3.191 | * |
dc.identifier.wosid | WOS:000279525300003 | * |
dc.author.google | Kim, Minji | * |
dc.author.google | Kim, Yangha | * |
dc.contributor.scopusid | 김양하(8524160300) | * |
dc.date.modifydate | 20240123090847 | * |