Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 오억수 | - |
dc.date.accessioned | 2016-08-27T02:08:59Z | - |
dc.date.available | 2016-08-27T02:08:59Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.other | OAK-5647 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/216341 | - |
dc.description.abstract | Syndecan-2, a transmembrane heparan Sulfate proteoglycan, is known to serve as an adhesion receptor, but details of the regulatory mechanism governing syndecan-2 cell adhesion and migration remain unclear. Here, we examined this regulatory mechanism, showing that overexpression of syndecan-2 enhanced collagen adhesion, cell migration and invasion of normal rat intestinal epithelial cells (RIE1), and increased integrin of alpha 2 expression levels. Interestingly, RIE1 cells transfected with either syndecan-2 or integrin of alpha 2 showed similar adhesion and migration patterns, and a function-blocking anti-integrin alpha 2 antibody abolished syndecan-2-mediated adhesion and migration. Consistent with these findings, transfection of integrin alpha 2 siRNA diminished syndecan-2-induced cell migration in HCT116 human colon cancer cells. Taken together. these results demonstrate a novel cooperation between syndecan-2 and integrin alpha 2 beta 1 in adhesion-mediated cell migration and invasion. This interactive dynamic might be a possible mechanism Underlying the tumorigenic activities of colon cancer cells. (C) 2009 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.subject | Syndecan-2 | - |
dc.subject | Integrin alpha 2 | - |
dc.subject | Adhesion | - |
dc.subject | Migration | - |
dc.subject | Invasion | - |
dc.subject | Colon cancer cell | - |
dc.title | Syndecan-2 overexpression regulates adhesion and migration through cooperation with integrin alpha 2 | - |
dc.type | Article | - |
dc.relation.issue | 2 | - |
dc.relation.volume | 384 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 231 | - |
dc.relation.lastpage | 235 | - |
dc.relation.journaltitle | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.identifier.doi | 10.1016/j.bbrc.2009.04.093 | - |
dc.identifier.wosid | WOS:000266462500018 | - |
dc.author.google | Choi, Sojoong | - |
dc.author.google | Kim, Yeonhee | - |
dc.author.google | Park, Haein | - |
dc.author.google | Han, Inn-Oc | - |
dc.author.google | Chung, Eunkyung | - |
dc.author.google | Lee, Sung-Yul | - |
dc.author.google | Kim, Yong-Bae | - |
dc.author.google | Lee, Jung Weon | - |
dc.author.google | Oh, Eok-Soo | - |
dc.author.google | Yi, Jae Youn | - |
dc.contributor.scopusid | 오억수(7101967153) | - |
dc.date.modifydate | 20230201093717 | - |