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dc.contributor.author서은경-
dc.date.accessioned2016-08-27T02:08:56Z-
dc.date.available2016-08-27T02:08:56Z-
dc.date.issued2008-
dc.identifier.issn1060-3271-
dc.identifier.otherOAK-5294-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/216305-
dc.description.abstractThe rhizomes of Anemarrhena asphodeloides Bunge (Liliaceae) are prescribed as crude drugs in herbal medication for the treatment of various diseases such as diabetes, inflammation, and platelet aggregation inhibition. A simple, sensitive, and precise reversed-phase liquid chromatographic method was developed to study the quantitative determination of 5 bioactive compounds from these rhizomes, namely, neomangiferin, mangiferin, isomangiferin, nyasol, and methylnyasol. Chromatographic analysis was performed on Capcell Pak C(18) column (150 x 4.6 mm, 3 mu m) with a mobile phase consisting of acetonitrile, methanol, and 0.1% formic acid at a flow rate of 1.00 mL/min. Quantitation was performed using a UV-visible detector at 260 nm. The method for the determination of reported medicinal agents was accurate and reproducible. Excellent linear behavior was observed over the investigated concentration range of 2.5-100.0 mu g/mL for neomangiferin; 1.5-60.0 mu g/mL for mangiferin; 0.5-20.0 mu g/mL for nyasol; and 0.2-20.0 mu g/mL for methylnyasol; correlation coefficient > 0.99. The intraday and interday precision over the concentration range of compounds was < 6.6% (relative standard deviation) and accuracy was between 94.9 and 109.3%. This method can be successfully applied for the analysis of medicinal compounds from the ethanolic extract of A. asphodeloides Bunge.-
dc.languageEnglish-
dc.publisherAOAC INT-
dc.titleSimultaneous Determination of Bioactive Xanthone Glycosides and Norlignans from Ethanolic Extract of Anemarrhena asphodeloides by Liquid Chromatography-
dc.typeArticle-
dc.relation.issue6-
dc.relation.volume91-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage1271-
dc.relation.lastpage1277-
dc.relation.journaltitleJOURNAL OF AOAC INTERNATIONAL-
dc.identifier.wosidWOS:000262118200006-
dc.identifier.scopusid2-s2.0-58449134302-
dc.author.googleIslam, M. Nurul-
dc.author.googleYoo, Hye Hyun-
dc.author.googleLee, Jun-
dc.author.googleNam, Joo Won-
dc.author.googleSeo, Eun Kyoung-
dc.author.googleJin, Changbae-
dc.author.googleKim, Dong-Hyun-
dc.contributor.scopusid서은경(7005953758)-
dc.date.modifydate20180104081001-
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약학대학 > 약학과 > Journal papers
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