We have successfully intercalated gadolinium (III) diethylenetriamine pentaacetic acid (Gd-DTPA) into layered double hydroxide (LDH). X-ray diffractometry, Infrared spectroscopy, and electron microscopic studies together with T(1)-weighed contrast image analyses revealed the possiblity of Gd-DTPA/LDH as in vivo magnetic resonance (MR) contrast nanoparticles.