Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이상국 | - |
dc.date.accessioned | 2016-08-27T02:08:45Z | - |
dc.date.available | 2016-08-27T02:08:45Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 0253-6269 | - |
dc.identifier.other | OAK-4369 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/216178 | - |
dc.description.abstract | Overproduction of prostaglandins has been considered in mediation of inflammation and carcinogenic process. On this line, the inhibitors of prostaglandin biosynthetic enzyme cyclooxygenase (COX) have played a role of anti-inflammatory and cancer chemopreventive agents. In our continuous efforts to search anti-inflammatory and chemopreventive agents from natural products, bioassay-guided fractionation led to the isolation of curdione from the rhizome of Curcuma zedoaria with the inhibitory effect on the production of prostaglandin E-2 in lipopolysaccharide (LPS)-stimulated mouse macrophage RAW 264.7 cells in a concentration-dependent manner (IC50 = 1-1 mu M). Mechanistic studies suggest that the suppression of cyclooxygenase-2 (COX-2) mRNA expression is, at least in part, involved in this inhibitory activity of curdione. | - |
dc.language | English | - |
dc.publisher | PHARMACEUTICAL SOC KOREA | - |
dc.subject | curdione | - |
dc.subject | Curcuma zedoaria | - |
dc.subject | prostaglandin E-2 | - |
dc.subject | cyclooxygenase-2 | - |
dc.title | Inhibition of inducible prostaglandin E-2 production and cyclooxygenase-2 expression by curdione from Curcuma zedoaria | - |
dc.type | Article | - |
dc.relation.issue | 10 | - |
dc.relation.volume | 30 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.index | KCI | - |
dc.relation.startpage | 1236 | - |
dc.relation.lastpage | 1239 | - |
dc.relation.journaltitle | ARCHIVES OF PHARMACAL RESEARCH | - |
dc.identifier.doi | 10.1007/BF02980264 | - |
dc.identifier.wosid | WOS:000250527000007 | - |
dc.author.google | Oh, O-Jin | - |
dc.author.google | Min, Hye-Young | - |
dc.author.google | Lee, Sang Kook | - |
dc.contributor.scopusid | 이상국(36067620500) | - |
dc.date.modifydate | 20211210153309 | - |