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DC Field	Value	Language
dc.contributor.author	손연수	*
dc.contributor.author	정병문	*
dc.date.accessioned	2016-08-27T02:08:25Z	-
dc.date.available	2016-08-27T02:08:25Z	-
dc.date.issued	2006	*
dc.identifier.issn	1773-2247	*
dc.identifier.other	OAK-3214	*
dc.identifier.uri	https://dspace.ewha.ac.kr/handle/2015.oak/215961	-
dc.description.abstract	A pH/temperature sensitive polymer of poly(aspartic acid) grafted with poly(propylene glycol) (PA-g-PPG) was prepared. The polymer showed lower critical solution temperature in water depending on the pH as well as ionic strength. As the temperature increased, the concentrated poly(propylene glycol) aqueous solution precipitated, whereas the concentrated aqueous solution of PA-g-PPG underwent sol-to-gel transition atpH 7.4. The dehydration of poly(propylene glycol) and ionic repulsion of aspartic acid drive gel formation atpH 7.4 over 30 similar to 50 degrees C. The PA-g-PPG is expected to be a useful in situ gel forming depot system for drug delivery and tissue engineering applications.	*
dc.language	English	*
dc.publisher	EDITIONS SANTE	*
dc.subject	poly(aspartic acid)	*
dc.subject	thermosensitive polymer	*
dc.subject	pH sensitive polymer	*
dc.subject	sol-gel transition	*
dc.subject	hydrogel	*
dc.title	pH/temperature sensitive poly(aspartic acid)-g-poly(propylene glycol)	*
dc.type	Article	*
dc.relation.issue	1	*
dc.relation.volume	16	*
dc.relation.index	SCI	*
dc.relation.index	SCIE	*
dc.relation.index	SCOPUS	*
dc.relation.startpage	71	*
dc.relation.lastpage	76	*
dc.relation.journaltitle	JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY	*
dc.identifier.wosid	WOS:000235957000011	*
dc.identifier.scopusid	2-s2.0-33644773735	*
dc.author.google	Cho, JY	*
dc.author.google	Lee, J	*
dc.author.google	Gutowska, A	*
dc.author.google	Tarasevich, BJ	*
dc.author.google	Sohn, YS	*
dc.author.google	Jeong, B	*
dc.contributor.scopusid	손연수(7201971323)	*
dc.contributor.scopusid	정병문(7102237959)	*
dc.date.modifydate	20240118155902	*