Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 김원기 | - |
dc.contributor.author | 이재철 | - |
dc.date.accessioned | 2016-08-27T02:08:14Z | - |
dc.date.available | 2016-08-27T02:08:14Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 0253-6269 | - |
dc.identifier.other | OAK-2364 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/215848 | - |
dc.description.abstract | Wogonin (5,7-dihydroxy-8-methoxyflavone), an active component originated from the root of Scutellaria baicalensis Georgi, has been reported to possess antioxidant and anti-inflammatory properties. In this study, we investigated the neuroprotective effect of wogonin in a focal cerebral ischemia rat model. Wogonin markedly reduced the infarct volume after 2 h middle cerebral artery occlusion followed by 22 h reperfusion. Wogonin decreased the production of nitric oxide and inflammatory cytokines such as TNF-alpha and IL-6 in lipopolisaccharicle-stimulated microglial cells. While wogonin reduced the activity of NF-kappaB, it did not change the activity of mitogen-activated protein kinases family members, p38, ERK and JNK. The lipopolisaccharicle-stimulated production of NO and cytokines was significantly blocked by various kinds of NF-kappaB inhibitors such as N-acetyl cysteine, pyrrolidinedithiocarbamate and MG-132. The data may indicate that wogonin has neuroprotective effect by preventing the over-activation of microglial cells, possibly by inactivating NF-kappaB signaling pathway. | - |
dc.language | English | - |
dc.publisher | PHARMACEUTICAL SOCIETY KOREA | - |
dc.subject | wogonin | - |
dc.subject | NF-kappa B | - |
dc.subject | microglia | - |
dc.subject | cytokine | - |
dc.subject | neuroprotection | - |
dc.title | Neuroprotective effect of wogonin: Potential roles of inflammatory cytokines | - |
dc.type | Article | - |
dc.relation.issue | 9 | - |
dc.relation.volume | 27 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.index | KCI | - |
dc.relation.startpage | 930 | - |
dc.relation.lastpage | 936 | - |
dc.relation.journaltitle | ARCHIVES OF PHARMACAL RESEARCH | - |
dc.identifier.doi | 10.1007/BF02975846 | - |
dc.identifier.wosid | WOS:000224106700009 | - |
dc.identifier.scopusid | 2-s2.0-16644397756 | - |
dc.author.google | Piao, HZ | - |
dc.author.google | Jin, SA | - |
dc.author.google | Chun, HS | - |
dc.author.google | Lee, JC | - |
dc.author.google | Kim, WK | - |
dc.contributor.scopusid | 김원기(34770946200) | - |
dc.date.modifydate | 20211210152058 | - |