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dc.contributor.author김원기-
dc.contributor.author이재철-
dc.date.accessioned2016-08-27T02:08:14Z-
dc.date.available2016-08-27T02:08:14Z-
dc.date.issued2004-
dc.identifier.issn0253-6269-
dc.identifier.otherOAK-2364-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/215848-
dc.description.abstractWogonin (5,7-dihydroxy-8-methoxyflavone), an active component originated from the root of Scutellaria baicalensis Georgi, has been reported to possess antioxidant and anti-inflammatory properties. In this study, we investigated the neuroprotective effect of wogonin in a focal cerebral ischemia rat model. Wogonin markedly reduced the infarct volume after 2 h middle cerebral artery occlusion followed by 22 h reperfusion. Wogonin decreased the production of nitric oxide and inflammatory cytokines such as TNF-alpha and IL-6 in lipopolisaccharicle-stimulated microglial cells. While wogonin reduced the activity of NF-kappaB, it did not change the activity of mitogen-activated protein kinases family members, p38, ERK and JNK. The lipopolisaccharicle-stimulated production of NO and cytokines was significantly blocked by various kinds of NF-kappaB inhibitors such as N-acetyl cysteine, pyrrolidinedithiocarbamate and MG-132. The data may indicate that wogonin has neuroprotective effect by preventing the over-activation of microglial cells, possibly by inactivating NF-kappaB signaling pathway.-
dc.languageEnglish-
dc.publisherPHARMACEUTICAL SOCIETY KOREA-
dc.subjectwogonin-
dc.subjectNF-kappa B-
dc.subjectmicroglia-
dc.subjectcytokine-
dc.subjectneuroprotection-
dc.titleNeuroprotective effect of wogonin: Potential roles of inflammatory cytokines-
dc.typeArticle-
dc.relation.issue9-
dc.relation.volume27-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.indexKCI-
dc.relation.startpage930-
dc.relation.lastpage936-
dc.relation.journaltitleARCHIVES OF PHARMACAL RESEARCH-
dc.identifier.doi10.1007/BF02975846-
dc.identifier.wosidWOS:000224106700009-
dc.identifier.scopusid2-s2.0-16644397756-
dc.author.googlePiao, HZ-
dc.author.googleJin, SA-
dc.author.googleChun, HS-
dc.author.googleLee, JC-
dc.author.googleKim, WK-
dc.contributor.scopusid김원기(34770946200)-
dc.date.modifydate20211210152058-
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자연과학대학 > 화학·나노과학전공 > Journal papers
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