Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 신윤용 | * |
dc.contributor.author | 김대기 | * |
dc.date.accessioned | 2016-08-27T02:08:11Z | - |
dc.date.available | 2016-08-27T02:08:11Z | - |
dc.date.issued | 2004 | * |
dc.identifier.issn | 0253-6269 | * |
dc.identifier.other | OAK-2236 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/215825 | - |
dc.description.abstract | Histone deacetylase inhibitors are new class of chemotherapeutic drugs able to induce tumor cell apoptosis and/or cell cycle arrest. Trichostatin A, an antifungal antibiotic, and HC-toxin are potent and specific inhibitors of histone deacetylase activity. In this study, we have examined the anti proliferative activities of trichostatin A and HC-toxin in estrogen receptor positive human breast cancer, T47D cells. Both trichostatin A and HC-toxin showed potent antiproliferative efficacy and cell cycle arrest at G(2)/M in T47D human breast cancer cells in a dose-dependent manner. Trichostatin A caused potent apoptosis of T47D human breast cancer cells and trichostatin A-induced apoptosis might be involved in an increase of caspase-3/7 activity. HC-toxin evoked apoptosis of T47D cells and HC-toxin induced apoptosis might not be mediated through direct increase in caspase-3/7 activity. We have identified potent activities of anti-proliferation, apoptosis, and cell cycle arrest of trichostatin A and HC-toxin in estrogen receptor positive human breast cancer cell line T47D. | * |
dc.language | English | * |
dc.publisher | PHARMACEUTICAL SOCIETY KOREA | * |
dc.subject | T47D cell | * |
dc.subject | trichostatin A | * |
dc.subject | HC-toxin | * |
dc.subject | histone deacetylase | * |
dc.title | Antiproliferative effect of trichostatin A and HC-toxin in T47D human breast cancer cells | * |
dc.type | Article | * |
dc.relation.issue | 6 | * |
dc.relation.volume | 27 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 640 | * |
dc.relation.lastpage | 645 | * |
dc.relation.journaltitle | ARCHIVES OF PHARMACAL RESEARCH | * |
dc.identifier.doi | 10.1007/BF02980164 | * |
dc.identifier.wosid | WOS:000222363000012 | * |
dc.identifier.scopusid | 2-s2.0-17344366283 | * |
dc.author.google | Joung, KE | * |
dc.author.google | Kim, DK | * |
dc.author.google | Sheen, YY | * |
dc.contributor.scopusid | 신윤용(6603872711) | * |
dc.contributor.scopusid | 김대기(35083694200) | * |
dc.date.modifydate | 20240118164500 | * |