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dc.contributor.author유충규-
dc.date.accessioned2016-08-27T02:08:44Z-
dc.date.available2016-08-27T02:08:44Z-
dc.date.issued2002-
dc.identifier.issn0731-7085-
dc.identifier.otherOAK-1218-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/215544-
dc.description.abstractA high-performance liquid chromatographic (HPLC) method was developed for the determination of a new isoquinolinedione derivative, 7-anilino-5,8-isoquinolinedione (IQO4), in rat plasma, urine, blood and tissue homogenates using diazepam as an internal standard. A 2 volume of acetonitrile was added to deproteinize the biological sample. A 50 mul aliquot of the supernatant was injected onto a C-18 reversed-phase column. The mobile phase, 0.05 M acetate buffer (pH 3):acetonitrile:methanol (40:40:20, v/v/v), was run at a flow rate of 1.5 ml/min. The column effluent was monitored using an ultraviolet detector set at 298 nm. The retention times for IQO4 and the internal standard were approximately 5 and 7 min, respectively. The detection limits of IQO4 in rat plasma, urine and tissue homogenates (including blood) were 0.05, 0.1 and 0.1 mug/ml, respectively. The coefficients of variation of the assay were below 9.4% for rat plasma, urine and tissue homogenates. No interferences from endogenous substances were found. (0 2002 Elsevier Science B.V. All rights reserved.-
dc.languageEnglish-
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD-
dc.subjectIQO4-
dc.subjectHPLC-
dc.subjectpharmacokinetics-
dc.titleDetermination of a new isoquinolinedione derivative, 7-anilino-5,8-isoquinolinedione, in plasma, urine and tissue homogenates by high-performance liquid chromatography-
dc.typeArticle-
dc.typeProceedings Paper-
dc.relation.issue3-
dc.relation.volume30-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage519-
dc.relation.lastpage526-
dc.relation.journaltitleJOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS-
dc.identifier.doi10.1016/S0731-7085(02)00398-9-
dc.identifier.wosidWOS:000178826400014-
dc.author.googleKim, SH-
dc.author.googleMoon, YJ-
dc.author.googleRyu, CK-
dc.author.googleLee, MG-
dc.contributor.scopusid유충규(15846918400)-
dc.date.modifydate20180104081001-
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약학대학 > 약학과 > Journal papers
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