Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 유충규 | - |
dc.date.accessioned | 2016-08-27T02:08:44Z | - |
dc.date.available | 2016-08-27T02:08:44Z | - |
dc.date.issued | 2002 | - |
dc.identifier.issn | 0731-7085 | - |
dc.identifier.other | OAK-1218 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/215544 | - |
dc.description.abstract | A high-performance liquid chromatographic (HPLC) method was developed for the determination of a new isoquinolinedione derivative, 7-anilino-5,8-isoquinolinedione (IQO4), in rat plasma, urine, blood and tissue homogenates using diazepam as an internal standard. A 2 volume of acetonitrile was added to deproteinize the biological sample. A 50 mul aliquot of the supernatant was injected onto a C-18 reversed-phase column. The mobile phase, 0.05 M acetate buffer (pH 3):acetonitrile:methanol (40:40:20, v/v/v), was run at a flow rate of 1.5 ml/min. The column effluent was monitored using an ultraviolet detector set at 298 nm. The retention times for IQO4 and the internal standard were approximately 5 and 7 min, respectively. The detection limits of IQO4 in rat plasma, urine and tissue homogenates (including blood) were 0.05, 0.1 and 0.1 mug/ml, respectively. The coefficients of variation of the assay were below 9.4% for rat plasma, urine and tissue homogenates. No interferences from endogenous substances were found. (0 2002 Elsevier Science B.V. All rights reserved. | - |
dc.language | English | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.subject | IQO4 | - |
dc.subject | HPLC | - |
dc.subject | pharmacokinetics | - |
dc.title | Determination of a new isoquinolinedione derivative, 7-anilino-5,8-isoquinolinedione, in plasma, urine and tissue homogenates by high-performance liquid chromatography | - |
dc.type | Article | - |
dc.type | Proceedings Paper | - |
dc.relation.issue | 3 | - |
dc.relation.volume | 30 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 519 | - |
dc.relation.lastpage | 526 | - |
dc.relation.journaltitle | JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | - |
dc.identifier.doi | 10.1016/S0731-7085(02)00398-9 | - |
dc.identifier.wosid | WOS:000178826400014 | - |
dc.author.google | Kim, SH | - |
dc.author.google | Moon, YJ | - |
dc.author.google | Ryu, CK | - |
dc.author.google | Lee, MG | - |
dc.contributor.scopusid | 유충규(15846918400) | - |
dc.date.modifydate | 20180104081001 | - |