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dc.contributor.author서명은-
dc.date.accessioned2016-08-27T02:08:40Z-
dc.date.available2016-08-27T02:08:40Z-
dc.date.issued2002-
dc.identifier.issn0253-2964-
dc.identifier.otherOAK-1010-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/215493-
dc.description.abstractComparison studies of the Quantitative Structure Activity Relationship (QSAR) methods with new imidazo-quinolinedione derivatives were conducted using Comparative Molecular Field Analysis (CoMFA), Comparative Molecular Similarity Indices Analysis (CoMSIA), and the Hologram Quantitative Structure Activity Relationship (HQSAR). When the CoMFA crossvalidation value. q(2), was 0.625, the Pearson correlation coefficient, r(2), was 0.973. In CoMSIA, q(2) was 0.52 and r(2) was 0.979. In the HQSAR, q(2) was 0.501 and r(2) was 0.924. The best result was obtained using the CoMSIA method according to a comparison of the calculated values with the real in vitro cytotoxic activities against human ovarian cancer cell lines.-
dc.languageEnglish-
dc.publisherKOREAN CHEMICAL SOC-
dc.subject-N-substituted imidazoquinoline-4,9-dione derivative-
dc.subjectComparative Molecular Field Analysis (CoMFA)-
dc.subjectComparative Molecular Similarity Indices Analysis (CoMSIA)-
dc.subjectHologram Quantitative Structure Activity Relationship (HQSAR)-
dc.subjecthuman ovarian cancer cell-
dc.titleComparison of QSAR methods (CoMFA, CoMSIA, HQSAR) of anticancer 1-N-substituted imidazoquinoiine-4,9-dione derivatives-
dc.typeArticle-
dc.relation.issue3-
dc.relation.volume23-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.indexKCI-
dc.relation.startpage417-
dc.relation.lastpage422-
dc.relation.journaltitleBULLETIN OF THE KOREAN CHEMICAL SOCIETY-
dc.identifier.wosidWOS:000174991400013-
dc.identifier.scopusid2-s2.0-0037139883-
dc.author.googleSuh, ME-
dc.author.googlePark, SY-
dc.author.googleLee, HJ-
dc.contributor.scopusid서명은(7103253844)-
dc.date.modifydate20180104081001-
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약학대학 > 약학과 > Journal papers
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