Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 배윤수 | * |
dc.date.accessioned | 2016-08-27T02:08:37Z | - |
dc.date.available | 2016-08-27T02:08:37Z | - |
dc.date.issued | 2001 | * |
dc.identifier.issn | 0264-6021 | * |
dc.identifier.other | OAK-893 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/215463 | - |
dc.description.abstract | Although interleukin-10 (IL-10) is known to contribute to inflammation and pathogenesis in mammalian organs, little is known about its precise role in the mammary gland. We found that IL-10 levels fluctuated during the mouse mammary cycle, showing little expression at the lactation stage and the highest expression at the involution stage. To reveal the effects of IL-10 on involution, expression profiles of apoptosis-related genes were examined in mice transgenic for IL-10 as well as in IL-10(-/-) mice. Mild inflammatory lesions by lymphocytes were observed in the mammary glands from four of seven transgenic lines at the lactation stage. It was striking that the expression of tumour-necrosis-factor-alpha -related apoptosis-inducing ligand (TRAIL) among the apoptosis-related genes was elevated approx. 7-fold in the transgenic mice, whereas others were almost unchanged. Furthermore, TRAIL was down-regulated 4-fold in the IL-10(-/-) mice at the involution stage. Elevated expression of TRAIL and of death receptor 4 (DR4) protein was identified at the involution stage of normal mammary glands as well as at the lactation stage of the IL-10 transgenic mice. These results indicate that the elevated expression of IL-10 at the involution stage recruits lymphocytes and induces the expression of TRAIL and DR4. These phenomena might partly contribute to apoptosis in the mammary epithelial cells for entering involution. | * |
dc.language | English | * |
dc.publisher | PORTLAND PRESS | * |
dc.subject | apoptosis | * |
dc.subject | death receptor | * |
dc.subject | mammary gland | * |
dc.title | Interleukin-10 up-regulates tumour-necrosis-factor-alpha-related apoptosis-inducing ligand (TRAIL) gene expression in mammary epithelial cells at the involution stage | * |
dc.type | Article | * |
dc.relation.volume | 360 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 31 | * |
dc.relation.lastpage | 38 | * |
dc.relation.journaltitle | BIOCHEMICAL JOURNAL | * |
dc.identifier.doi | 10.1042/0264-6021:3600031 | * |
dc.identifier.wosid | WOS:000172466900004 | * |
dc.author.google | Sohn, BH | * |
dc.author.google | Moon, HB | * |
dc.author.google | Kim, TY | * |
dc.author.google | Kang, HS | * |
dc.author.google | Bae, YS | * |
dc.author.google | Lee, KK | * |
dc.author.google | Kim, SJ | * |
dc.contributor.scopusid | 배윤수(15031067200) | * |
dc.date.modifydate | 20240415133331 | * |