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Synthesis of novel D- and L-3 '-deoxy-3 '-C-hydroxymethyl nucleoside with exocyclic methylene as potential ribonucleotide reductase inhibitor

Title
Synthesis of novel D- and L-3 '-deoxy-3 '-C-hydroxymethyl nucleoside with exocyclic methylene as potential ribonucleotide reductase inhibitor
Authors
Chun, MWKim, MJJo, UHKim, JHKim, HDJeong, LS
Ewha Authors
정낙신
SCOPUS Author ID
정낙신scopus
Issue Date
2001
Journal Title
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
ISSN
1525-7770JCR Link
Citation
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS vol. 20, no. 4-7, pp. 703 - 706
Publisher
MARCEL DEKKER INC
Indexed
SCIE; SCOPUS WOS
Document Type
Article

Proceedings Paper
Abstract
D- and L-3'-Deoxy-3'-C-hydroxymethyl thymidine substituted with exocyclic methylene at 2'-position were synthesized, starting from D- and L-xylose as potential ribonucleotide reductase inhibitor, respectively, but they were found to be inactive against several tumor cell lines.
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DOI
10.1081/NCN-100002355
Appears in Collections:
약학대학 > 약학과 > Journal papers
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