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dc.contributor.author신명헌-
dc.date.accessioned2016-08-27T02:08:31Z-
dc.date.available2016-08-27T02:08:31Z-
dc.date.issued2001-
dc.identifier.issn1017-7825-
dc.identifier.otherOAK-629-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/215400-
dc.description.abstractThe in vitro activity of 2,2'-dipyridyl, an iron-chelator, against clinical isolates of Trichomonas vaginalis. Candida albicans, and Gardnerella vaginalis was evaluated and compared with those of four other vaginal suppositories. ornidazole, clotrimazole, povidone-iodine. and Cenacert(R) (Methylbenzethonium Chloride mixed with 9-aminoacrydine undecylenate and hydrochloric acid N-myristyl-3-hydroxy butyl amine). The 2.2'-dipyridyl killed T. vaginalis and G. vaginalis at concentrations of 410 mug/ml and 205 mug/ml, respectively, however, this agent was less active against C. albicans (80% of which was inhibited at 410 mug/ml). The inhibition of these three pathogens by 2,2'-dipyridyl was similar to clotrimazole. In addition, the effect of 2,2'-dipyridyl on the ultrastructure of T. vaginalis. C, albicans, and G. vaginalis was examined. Transmission electron microscopy indicated that 2,2'-dipyridyl induced modifications of the cellular contents and cell envelope concomitant with the degradation of the three pathogens. These results suggest that 2.2'-dipyridyl has an inhibitory effect on C. albicans and G. vaginalis, as well as T. vaginalis.-
dc.languageEnglish-
dc.publisherKOREAN SOC APPLIED MICROBIOLOGY-
dc.subject2,2 '-dipyridyl-
dc.subjectTrichomonas vaginalis-
dc.subjectCandida albicans-
dc.subjectGardnerella vaginalis-
dc.titleIn vitro activities of 2,2 '-dipyridyl against Trichomonas vaginalis, Candida albicans, and Gardnerella vaginalis-
dc.typeArticle-
dc.relation.issue1-
dc.relation.volume11-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.indexKCI-
dc.relation.startpage124-
dc.relation.lastpage130-
dc.relation.journaltitleJOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY-
dc.identifier.wosidWOS:000167320200021-
dc.author.googleRyu, JS-
dc.author.googleMin, DY-
dc.author.googleKim, MC-
dc.author.googleKim, NS-
dc.author.googleShin, MH-
dc.date.modifydate20200911081002-
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의과대학 > 의학과 > Journal papers
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