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Design and syntheses of 2-oxiranecarboxylate derivatives and their hypoglycemic activities
- Title
- Design and syntheses of 2-oxiranecarboxylate derivatives and their hypoglycemic activities
- Authors
- Jew, S; Kim, E; Je, S; Zhao, LX; Kim, H; Park, W; Ko, K; Kim, W; Kim, HJ; Cheong, JH; Lee, ES
- Ewha Authors
- 김화정
- SCOPUS Author ID
- 김화정
- Issue Date
- 2000
- Journal Title
- HETEROCYCLES
- ISSN
- 0385-5414
- Citation
- HETEROCYCLES vol. 52, no. 3, pp. 1087 - +
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Indexed
- SCI; SCIE; SCOPUS
- Document Type
- Article
- Abstract
- A series of 2-oxiranecarboxylate derivatives were prepared as carnitine palmitoyl transferase I (CPT-I) inhibitors for the development of new antidiabetic agents. The syntheses and biological activities were reported. The most promising derivative (13b) showed 2.5 times more hypoglycemic activity and 2 times lower acute toxicity compared to Etomoxir ((3)).
- Appears in Collections:
- 약학대학 > 약학과 > Journal papers
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