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Acyl-CoA : cholesterol acyltransferase inhibitory activity of lignans isolated from Schizandra, Machilus and Magnolia species

Title
Acyl-CoA : cholesterol acyltransferase inhibitory activity of lignans isolated from Schizandra, Machilus and Magnolia species
Authors
Kwon, BMJung, HJLim, JHKim, YSKim, MKKim, YKBok, SHBae, KHLee, IR
Ewha Authors
이인란
SCOPUS Author ID
이인란scopusscopus
Issue Date
1999
Journal Title
PLANTA MEDICA
ISSN
0032-0943JCR Link
Citation
PLANTA MEDICA vol. 65, no. 1, pp. 74 - 76
Publisher
GEORG THIEME VERLAG
Indexed
SCIE; SCOPUS WOS
Document Type
Letter
Abstract
Fifteen lignans were isolated from the fruits of Schizandra chinensis, the leaves of Machilus thunbergii, and the flower buds of Magnolia denudata. They were identified as gomisins, schizandrin, wuweizisu, schizantherin, licarins, and machilin, which inhibited rat liver ACAT with IC50 values of 25 - 200 mu M. Gomisin N is the most potent inhibitor with IC50 value of 25 mu M in these lignans.
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DOI
10.1055/s-2006-960443
Appears in Collections:
약학대학 > 약학과 > Journal papers
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