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점막하 Midazolam의 병용투여 시 BIS 분석을 이용한 진정 평가
- 점막하 Midazolam의 병용투여 시 BIS 분석을 이용한 진정 평가
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- 임상치의학대학원 임상치의학과임상소아치과학전공
- 이화여자대학교 임상치의학대학원
- Purpose : The aim of this study was to examine the difference of the depth of sedation using the Bispectral index assessment with and without the added submucosal Midazolam to oral Chloral hydrate and Hydroxyzine for pediatric patients
Methods : Twenty seven sedation cases were performed in this study. Selection criteria included good health (ASA I), 2 to 6 years of age, the need for sedation to receive dental treatment including anesthesia, and restorative procedure over at least two teeth. Patients were randomly classified into one group taking oral CH(60mg/kg) and Hydroxyzine(1mg/kg) and the other group recieving CH (60mg/kg) , Hydroxyzine(1mg/kg) and SM midazolam(0.1mg/kg). Nitrous Oxide(50%) was used for both group during sedation. Patients were monitored using a pulse oximeter and a BIS monitor. A behavior scale was rated as quiet(Q), crying(C), movement(M), or struggling(S) every 2 minutes watching a recorded videotape. For evaluating the depth of sedation, data including Pulse rate(PR), Saturation percentage of O2(SpO2) and the behavior scale were checked every 2 minutes and mean BIS index calculated every 2 minutes was collected for only 40 minutes from the beginning of treatment and was analyzed using T-test and Levene’s test.
Result : Analysis showed a significant difference in mean BIS index and SD during sedation across two groups(P<0.001). The group of patients injected with SM Midazolam in addition to oral CH and Hydroxyzine showed a lower mean BIS index and a narrower SD. PR and SpO2 for both groups remained within the normal values.
Conclusion : SM Midazolam improved the sedation quality by deepening sedation depth without compromising safety and enabled the sedation pattern to be kept more stable.
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