Adrenergic 효능제 및 차단제가 Corticosterone산생에 미치는 효과

Abstract

Norepinephrine과 epinephrine은 stress상태를 일으킨다는 보고가 있으며, stress상태하에서는 shock상을 회복하고자 corticosterone 산생이 증가한다는 보고가 있어, α- adrenergic과 β-adrenergic 작용이 Corticosterone산생에 미치는 효과를 알아보고자, 흰쥐에게 norepinephrine , phentolamine, isoproterenol, Propranolol을 주사하고 흰쥐의 부신을 적출하여 부신 중의 corticosterone함량을 fluorometric method로 측정하여 다음과 같은 결과를 얻었다. 1) α-adrenergic 작용은 부신 중의 corticosterone 산생 량을 감소시켰다. 2) β- adrenergic 작용은 부신 중의 corticosterone 산생 량을 증가시켰다. 3) Stress 하에 나타난 corticosterone양의 증가는 β- adrenergic기전에 의한 것이라 사료된다.;It has been reported that stress was induced by norepinephrine and epinephrine and under the conditions the amount of corticosterone was increased to recover the shock. The purpose of this work to investigate the effect of α -adrenergic and β -adrenergic mechanism on corticosteroidogenesis. Norepinephrine, phentolamine, isorroterenol and propranolol were injected into rats and the adrenals were taken to measure the corticosterone contents by fluorometric method. The summarized results are as follows; 1) α -adrenergic agonist didn't change the corticosterone contents in the adrenals, but α -adrenergic antagonist increased the corticosterone contents in the adrenals. 2) β -adrenergic agonist increased the corticosterone contents in the adrenals, but β -adrenergic antagonist didn't change the corticosterone contents in the adrenals. 3) Under the stress, the increase of corticosterone seemed to accomplish by β -adrenergic mechanism.