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Detection of bladder tumor cells using motion features in urine
- Title
- Detection of bladder tumor cells using motion features in urine
- Authors
- Kim; Minsuk
- Ewha Authors
- 김민석
- SCOPUS Author ID
- 김민석
![scopus](/images/layout/icon2.png)
- Issue Date
- 2024
- Journal Title
- Journal of Analytical Science and Technology
- ISSN
- 2093-3134
- Citation
- Journal of Analytical Science and Technology vol. 15, no. 1
- Keywords
- Bladder carcinoma; Computational tool; Microfluidic system; Motion microscopy; Vibration
- Indexed
- SCIE; SCOPUS
![scopus](/images/layout/scopus2.gif)
- Document Type
- Article
- Abstract
- Urinary exfoliated tumor cells have emerged as promising biomarkers for predicting, diagnosing, and guiding therapy in bladder cancer. Several methodologies based on biological and physical differences between normal cells and malignant tumor cells have been developed over the past few years. However, these methods still did not have sufficient sensitivity or specificity. In this study, a remote analysis protocol was devised utilizing motion microscopy. This technique amplifies vibrations within a recorded video by re-rendering motions, thereby generating highly magnified visuals. This approach aims to detect dynamic motions that may not be perceptible to the human eye under normal observation. Remarkably, motion microscopy unveiled discernible fluctuations surrounding bladder malignant tumor cells, which we referred to herein as cellular trail. The cellular trails were predominantly evident at around 1 Hz in amplified video images, with a velocity of 22 μm/s. Moreover, cellular trails were observed regardless of whether they were in a non-Newtonian or Newtonian fluid environment. Significantly, this phenomenon was distinguishable even in urine samples. In conclusion, we suggest motion microscopy as an innovative approach for detecting urinary malignant tumors with potential clinical utility as a complementary tool to cytology. © The Author(s) 2024.
- DOI
- 10.1186/s40543-024-00451-3
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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