Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이상은 | - |
dc.date.accessioned | 2024-08-30T16:31:13Z | - |
dc.date.available | 2024-08-30T16:31:13Z | - |
dc.date.issued | 2024 | - |
dc.identifier.issn | 1941-9651 | - |
dc.identifier.other | OAK-35578 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/269568 | - |
dc.description.abstract | BACKGROUND: We assessed whether combinations of cardiometabolic risk factors independently predict coronary plaque progression (PP) and major adverse cardiovascular events in patients with stable coronary artery disease. METHODS: Patients with known or suspected stable coronary artery disease (60.9±9.3 years, 55.4% male) undergoing serial coronary computed tomography angiographies (≥2 years apart), with clinical characterization and follow-up (N=1200), were analyzed from the PARADIGM study (Progression of Atherosclerotic Plaque Determined by Computed Tomographic Angiography Imaging). Plaque volumes measured in coronary segments (≥2 mm in diameter) were summed to provide whole heart plaque volume (mm3) and percent atheroma volume (plaque volume/vessel volume×100; %) per patient at baseline and follow-up. Rapid PP was defined as a percent atheroma volume increase of ≥1.0%/y. Major adverse cardiovascular events included nonfatal myocardial infarction, death, and unplanned coronary revascularization. RESULTS: In an interscan period of 3.2 years (interquartile range, 1.9), rapid PP occurred in 341 patients (28%). At multivariable analysis, the combination of cardiometabolic risk factors defined as metabolic syndrome predicted rapid PP (odds ratio, 1.51 [95% CI, 1.12–2.03]; P=0.007) together with older age, smoking habits, and baseline percent atheroma volume. Among single cardiometabolic variables, high fasting plasma glucose (diabetes or fasting plasma glucose >100 mg/dL) and low HDL-C (high-density lipoprotein cholesterol; <40 mg/dL in males and <50 mg/dL in females) were independently associated with rapid PP, in particular when combined (odds ratio, 2.37 [95% CI, 1.56–3.61]; P<0.001). In a follow-up of 8.23 years (interquartile range, 5.92–9.53), major adverse cardiovascular events occurred in 201 patients (17%). At multivariable Cox analysis, the combination of high fasting plasma glucose with high systemic blood pressure (treated hypertension or systemic blood pressure >130/85 mm Hg) was an independent predictor of events (hazard ratio, 1.79 [95% CI, 1.10–2.90]; P=0.018) together with family history, baseline percent atheroma volume, and rapid PP. CONCLUSIONS: In patients with stable coronary artery disease, the combination of hyperglycemia with low HDL-C is associated with rapid PP independently of other risk factors, baseline plaque burden, and treatment. The combination of hyperglycemia with high systemic blood pressure independently predicts the worse outcome beyond PP. © 2024 American Heart Association, Inc. | - |
dc.description.sponsorship | Lippincott Williams and Wilkins | - |
dc.language | English | - |
dc.subject | cardiometabolic risk factors | - |
dc.subject | cholesterol | - |
dc.subject | computed tomography angiography | - |
dc.subject | coronary artery disease | - |
dc.subject | HDL | - |
dc.subject | hyperglycemia | - |
dc.subject | hypertension | - |
dc.subject | metabolic syndrome | - |
dc.title | Rapid Plaque Progression Is Independently Associated With Hyperglycemia and Low HDL Cholesterol in Patients With Stable Coronary Artery Disease: A PARADIGM Study | - |
dc.type | Article | - |
dc.relation.issue | 7 | - |
dc.relation.volume | 17 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | e016481 | - |
dc.relation.journaltitle | Circulation: Cardiovascular Imaging | - |
dc.identifier.doi | 10.1161/CIRCIMAGING.123.016481 | - |
dc.identifier.wosid | WOS:001269170300009 | - |
dc.identifier.scopusid | 2-s2.0-85198920971 | - |
dc.author.google | Ilan | - |
dc.author.google | Hadamitzky | - |
dc.author.google | Martin | - |
dc.author.google | Jin Kim | - |
dc.author.google | Yong | - |
dc.author.google | Kwon Lee | - |
dc.author.google | Byoung | - |
dc.author.google | Leipsic | - |
dc.author.google | Jonathon A. | - |
dc.author.google | Marques | - |
dc.author.google | Hugo | - |
dc.author.google | Gonçalves | - |
dc.author.google | Pedro de Araújo | - |
dc.author.google | Pontone | - |
dc.author.google | Gianluca | - |
dc.author.google | Shin | - |
dc.author.google | Sanghoon | - |
dc.author.google | Stone | - |
dc.author.google | Peter H. | - |
dc.author.google | Samady | - |
dc.author.google | Habib | - |
dc.author.google | Virmani | - |
dc.author.google | Renu | - |
dc.author.google | Narula | - |
dc.author.google | Jagat | - |
dc.author.google | Shaw | - |
dc.author.google | Leslee J. | - |
dc.author.google | Bax | - |
dc.author.google | Jeroen J. | - |
dc.author.google | Lin | - |
dc.author.google | Fay Y. | - |
dc.author.google | Min | - |
dc.author.google | James K. | - |
dc.author.google | Chang | - |
dc.author.google | Hyuk-Jae | - |
dc.author.google | Neglia | - |
dc.author.google | Danilo | - |
dc.author.google | Caselli | - |
dc.author.google | Chiara | - |
dc.author.google | Maffei | - |
dc.author.google | Erica | - |
dc.author.google | Cademartiri | - |
dc.author.google | Filippo | - |
dc.author.google | Meloni | - |
dc.author.google | Antonella | - |
dc.author.google | Bossone | - |
dc.author.google | Eduardo | - |
dc.author.google | Saba | - |
dc.author.google | Luca | - |
dc.author.google | Lee | - |
dc.author.google | Sang-Eun | - |
dc.author.google | Min Sung | - |
dc.author.google | Ji | - |
dc.author.google | Andreini | - |
dc.author.google | Daniele | - |
dc.author.google | Al-Mallah | - |
dc.author.google | Mouaz H. | - |
dc.author.google | Budoff | - |
dc.author.google | Matthew J. | - |
dc.author.google | Chinnaiyan | - |
dc.author.google | Kavitha | - |
dc.author.google | Choi | - |
dc.author.google | Jung Hyun | - |
dc.author.google | Chun | - |
dc.author.google | Eun Ju | - |
dc.author.google | Conte | - |
dc.author.google | Edoardo | - |
dc.author.google | Gottlieb | - |
dc.contributor.scopusid | 이상은(57213176330) | - |
dc.date.modifydate | 20240830120204 | - |