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자연과학대학
화학·나노과학전공
Journal papers
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Poly(l-threonine-co-l-threonine Succinate) Thermogels for Sustained Release of Lixisenatide
Title
Poly(l-threonine-co-l-threonine Succinate) Thermogels for Sustained Release of Lixisenatide
Authors
Park
;
Jin Kyung
;
Piao
;
Zhengyu
;
Lee
;
Hyun Jung
;
Jeong
;
Byeongmoon
Ewha Authors
정병문
SCOPUS Author ID
정병문
Issue Date
2024
Journal Title
Biomacromolecules
ISSN
1525-7797
Citation
Biomacromolecules vol. 25, no. 8, pp. 4946 - 4955
Indexed
SCIE; SCOPUS
Document Type
Article
Abstract
Negatively charged poly(l-Thr-co-l-Thr succinate) (PTTs) was developed as a new thermogel. Aqueous PTT solutions underwent thermogelation over a concentration range of 6.0-8.3 wt %. Dynamic light scattering, FTIR, 1H NMR, and COSY spectra revealed the partial strengthening of the β-sheet conformation and the dehydration of PTTs during the transition. Extendin-4 was released from the PTTs thermogel with a large initial burst release, whereas positively charged lixisenatide significantly reduced its initial burst release to 25%, and up to 77% of the dose was released from the gel over 14 days. In vivo study revealed a high plasma concentration of lixisenatide over 5 days and hypoglycemic efficacy was observed for type II diabetic rats over 7-10 days. The biocompatible PTTs were degraded by subcutaneous enzymes. This study thus demonstrates an effective strategy for reducing the initial burst release of protein drugs from thermogels with the introduction of electrostatic interactions between the drug and the thermogel. © 2024 American Chemical Society.
DOI
10.1021/acs.biomac.4c00376
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