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Air pollution and acute kidney injury with comorbid disease: A nationwide case-crossover study in South Korea
- Title
- Air pollution and acute kidney injury with comorbid disease: A nationwide case-crossover study in South Korea
- Authors
- Min; Jieun; Lee; Whanhee; Kang; Duk-Hee; Ahn; Seoyeong; Kim; Ayoung; Cinoo; Oh; Jongmin; Jang; Hyemin; Ho Jo; Chor; Park; Jinah; Moon; Jeongmin; Sooyoung; Jungsil; Minho; Kwag; Youngrin; Ha; Eunhee
- Ewha Authors
- 하은희; 강덕희; 곽영린
- SCOPUS Author ID
- 하은희
; 강덕희
; 곽영린![scopus](/images/layout/icon2.png)
- Issue Date
- 2024
- Journal Title
- Environmental Research
- ISSN
- 1393-9351
- Citation
- Environmental Research vol. 260
- Keywords
- Acute kidney injury; Air pollution; Comorbid disease; Emergency department; O<sub>3</sub>; PM<sub>2.5</sub>
- Indexed
- SCIE; SCOPUS
![scopus](/images/layout/scopus2.gif)
- Document Type
- Article
- Abstract
- Emerging evidence suggests that air pollution is a significant contributor to the global burden of kidney disease. Although acute kidney injury (AKI) is a common secondary event in ill patients, evidence regarding the association between air pollution and AKI accompanied by specific comorbidities is limited. This study aimed to estimate the association between short-term exposure to air pollution (fine particulate matter ≤2.5 μm [PM2.5] and ozone [O3]) and incident AKI by comorbid diseases using the Korea National Health Information Database (NHID). Total of 160,390 incident AKI cases, defined as an emergency department (ED) visit due to AKI, were observed within the period 2015–2021 in inland South Korea. A time-stratified case-crossover design was applied for PM2.5 and O3 individually, using a conditional logistic regression model within each case and its own control (three or four days of the same day of the week in the same month) to estimate the association between short-term air pollution exposure and ED visits due to AKI. Short-term exposure to PM2.5 and O3 was associated with ED visits due to AKI with ORs of 1.008 (95% confidence interval [CI]: 0.999, 1.017) and 1.019 (95% CI: 1.005, 1.033) for an interquartile range (IQR) increase in lag 0–1 day PM2.5 and O3 respectively, although OR for PM2.5 was marginally significant. The odds of incident AKI associated with PM2.5 was evident in conjunction with ischemic heart disease, cerebrovascular disease, gastrointestinal bleeding, and pneumonia. For O3, the estimated odds was prominent for AKI with ischemic heart disease. In addition, the comorbid disease-specific odds of AKI attributed to air pollution varied by sex and age. Our findings provide epidemiological evidence of a plausible mechanism between air pollution and incident AKI and suggest the need for personalized AKI prevention strategies attributed to air pollution. © 2024
- DOI
- 10.1016/j.envres.2024.119608
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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