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Mesh-shaped absorbable hemostatic hydrogel patch fabricated with marine organism-derived protein biomaterials with contact-activated blood coagulation for application in visceral surgery
- Title
- Mesh-shaped absorbable hemostatic hydrogel patch fabricated with marine organism-derived protein biomaterials with contact-activated blood coagulation for application in visceral surgery
- Authors
- Lee; Jaeyun; Kim; Eunjin; Ki-Joo; Hyo Jeong; Park; Tae Yoon; Jeon; Eun Young; Rhie; Jong Won; Joo; Kye Il; Cha; Hyung Joon
- Ewha Authors
- 주계일
- SCOPUS Author ID
- 주계일
![scopus](/images/layout/icon2.png)
- Issue Date
- 2024
- Journal Title
- Chemical Engineering Journal
- ISSN
- 1385-8947
- Citation
- Chemical Engineering Journal vol. 494
- Keywords
- Absorbable hemostatic agent; Blood coagulation; Lyophilized hydrogel patch; Mussel adhesive protein; Sea anemone silk-like protein
- Indexed
- SCIE; SCOPUS
![scopus](/images/layout/scopus2.gif)
- Document Type
- Article
- Abstract
- The utilization of efficacious hemostatic agents in surgical procedures has the potential to enhance operational efficacy, expedite patient recovery, and diminish the need for blood transfusions. However, in cases of excessive bleeding, few commercial hemostatic agents can maintain contact with the bleeding site and perform hemostatic functions effectively. In the present work, we propose a mesh-shaped absorbable lyophilized hemostatic hydrogel patch with excellent biodegradability, wet tissue adhesion ability, strong structural properties, and good blood coagulation activity by integrating the beneficial properties of two marine organism-derived bioengineered protein biomaterials, sea anemone silk-like protein (aneroin) and mussel adhesive protein (MAP). The hemostatic efficacy of the developed hydrogel patch was thoroughly evaluated using in vitro and in vivo experiments. The mesh-shaped hemostatic hydrogel patch exhibited the ability to absorb plasma upon contact with blood, adhere to surfaces, and facilitate aggregation of blood components, hence enhancing the process of blood coagulation. Using animal liver damage models, we confirmed that the hemostatic hydrogel patch could significantly enhance hemostatic capabilities by reducing clotting time and blood loss while exhibiting minimal inflammation and toxicity when remaining within the body. Thus, our proposed absorbable hemostatic hydrogel patch demonstrated great potential for use as a novel adhesive hemostatic agent for application in visceral surgery. © 2024 Elsevier B.V.
- DOI
- 10.1016/j.cej.2024.153062
- Appears in Collections:
- 공과대학 > 화공신소재공학과 > Journal papers
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