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Real-World Effectiveness of Biologics in Patients With Severe Asthma: Analysis of the KoSAR
- Title
- Real-World Effectiveness of Biologics in Patients With Severe Asthma: Analysis of the KoSAR
- Authors
- Park; So-Young; Lee; Sun-Kyung; Song; Woo-Jung; Kim; Min-Hye; Ban; Ga-Young; Joo-Hee; Byung-Keun; Kwon; Jae-Woo; Sohn; Kyoung-Hee; Hwa Young; Jung; Chan-Sun; Kang; Sung-Yoon; Yang; Min Suk; Jae Hyun; Jang; An-Soo; So Ri; Taehoon; Rhee; Chin Kook; Heung-Woo; Sang-Hoon; Chang; Yoon-Seok; Koh; Young-Il; Byung-Jae; Hae-Sim; Sang-Heon; Cho; You Sook
- Ewha Authors
- 김민혜
- SCOPUS Author ID
- 김민혜
![scopus](/images/layout/icon2.png)
- Issue Date
- 2024
- Journal Title
- Allergy, Asthma and Immunology Research
- ISSN
- 2092-7355
- Citation
- Allergy, Asthma and Immunology Research vol. 16, no. 3, pp. 253 - 266
- Keywords
- Asthma; dupilumab; eosinophils; lung function; mepolizumab; omalizumab; reslizumab; rhinosinusitis
- Indexed
- SCIE; SCOPUS; KCI
![scopus](/images/layout/scopus2.gif)
- Document Type
- Article
- Abstract
- Purpose: Severe asthma is associated with high morbidity and healthcare utilization; however, treatment options for these patients are limited. This study aimed to determine the therapeutic effects of biologics in clinical practice. Methods: This multicenter, retrospective cohort study included 136 patients who received biologics for at least 4 months between September 2017 and July 2022 at 25 medical centers affiliated with the Korean Severe Asthma Registry (KoSAR). The study evaluated the treatment effects, including acute exacerbation rates, maintenance of oral corticosteroid dosages, lung function, quality of life, blood eosinophil count, and fractional exhaled nitric oxide (FeNO) levels, by comparing measurements before and after 4 months of biologic treatment. Responses for each medication was evaluated based on the Global Evaluation of Treatment Effectiveness score, and any adverse reactions were summarized. Results: With the administration of biologics over the course of 4 months, there was a reduction in asthma acute exacerbations, a significant improvement in lung function, and a significant decrease in daily maintenance dose of oral steroid. Blood eosinophil counts decreased in the mepolizumab and reslizumab groups, while FeNO levels decreased only in the dupilumab group. The Asthma Control Test, Quality of Life Questionnaire for Adult Korean Asthmatics, and the EuroQol-visual analogue scale scores showed a significant improvement. Most patients (80.15%) responded to the biologic treatment. Meanwhile, non-responders often had chronic rhinosinusitis as a comorbidity, exhibited lower lung function, and required higher doses of oral steroids. No severe adverse events were reported. Conclusions: Biologics are highly effective in Korean patients with Type 2 severe asthma, significantly reducing acute exacerbation rates and doses of oral corticosteroids, while also improving lung function. Therefore, it seems beneficial to administer biologics without any restrictions to patients exhibiting Type 2 severe asthma. Copyright © 2024 The Korean Academy of Asthma, Allergy and Clinical Immunology •
- DOI
- 10.4168/aair.2024.16.3.253
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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