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Characterization of Codeine Treatment Responders Among Patients with Refractory or Unexplained Chronic Cough: A Prospective Real-World Cohort Study
- Title
- Characterization of Codeine Treatment Responders Among Patients with Refractory or Unexplained Chronic Cough: A Prospective Real-World Cohort Study
- Authors
- Oh; Ji-Yoon; Kang; Sung-Yoon; Noeul; Won; Ha-Kyeong; Jo; Eun-Jung; Lee; Seung-Eun; Ji-Hyang; Shim; Ji-Su; Kim; Young-Chan; Yoo; Youngsang; An; Jin; Hwa Young; Park; So-Young; Mi-Yeong; Ji-Ho; Byung-Keun; Han-Ki; Min-Hye; Sae-Hoon; Sang-Heon; Chang; Yoon-Seok; Sang-Hoon; Byung-Jae; Chung; Kian Fan; Cho; Song; Woo-Jung
- Ewha Authors
- 김민혜
- SCOPUS Author ID
- 김민혜
- Issue Date
- 2024
- Journal Title
- Lung
- ISSN
- 0341-2040
- Citation
- Lung vol. 202, no. 2, pp. 97 - 106
- Keywords
- Codeine; Cough; Real-world study; Treatment responders
- Publisher
- Springer
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Purpose: Codeine is a narcotic antitussive often considered for managing patients with refractory or unexplained chronic cough. This study aimed to evaluate the proportion and characteristics of patients who responded to codeine treatment in real-world practice. Methods: Data from the Korean Chronic Cough Registry, a multicenter prospective cohort study, were analyzed. Physicians assessed the response to codeine based on the timing and degree of improvement after treatment initiation. Follow-up assessments included the Leicester Cough Questionnaire and cough severity visual analog scale at six months. In a subset of subjects, objective cough frequency was evaluated following the initiation of codeine treatment. Results: Of 305 patients, 124 (40.7%) responded to treatments based on anatomic diagnostic protocols, while 181 (59.3%) remained unexplained or refractory to etiological treatments. Fifty-one subjects (16.7%) were classified as codeine treatment responders (those showing a rapid and clear response), 57 (18.7%) as partial responders, and 62 (20.3%) as non-responders. Codeine responders showed rapid improvement in objective cough frequency and severity scores within a week of the treatment. At 6 months, responders showed significantly improved scores in cough scores, compared to non-responders. Several baseline parameters were associated with a more favorable treatment response, including older age, non-productive cough, and the absence of heartburn. Conclusions: Approximately 60% of chronic cough patients in specialist clinics may require antitussive drugs. While codeine benefits some, only a limited proportion (about 20%) of patients may experience rapid and significant improvement. This underscores the urgent need for new antitussive drugs to address these unmet clinical needs. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.
- DOI
- 10.1007/s00408-024-00674-6
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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