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Risk factor control and cardiovascular events in patients with type 2 diabetes mellitus

Title
Risk factor control and cardiovascular events in patients with type 2 diabetes mellitus
Authors
SongDo KyeongHongYoung SunSungYeon-AhLeeHyejin
Ewha Authors
성연아홍영선이혜진송도경
SCOPUS Author ID
성연아scopus; 홍영선scopus; 이혜진scopus; 송도경scopus
Issue Date
2024
Journal Title
PLoS ONE
ISSN
1932-6203JCR Link
Citation
PLoS ONE vol. 19, no. 2-2월
Publisher
Public Library of Science
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Since patients with type 2 diabetes mellitus (T2DM) have an increased risk of cardiovascular events, interventions addressing risk factors reduce the incidence of cardiovascular disease (CVD) events. This study aimed to evaluate the difference in the incidence of CVD events according to risk factor control in patients with diabetes with and without cardio-renal disease. Methods We analyzed 113,909 patients with diabetes and 290,339 without diabetes using data released by the National Health Insurance Service (NHIS). Results Among patients with diabetes with four or five poorly controlled risk factors, hazard ratio for CVD events was 1.19 (95% confidence interval [CI], 1.06–1.34) in patients with cardio-renal disease and 2.31 (95% CI, 1.95–2.74) in patients without cardio-renal disease compared to patients with diabetes without risk factors. In subjects with diabetes and cardio-renal disease, patients with four or five poorly controlled risk factors had a higher risk of CVD mortality compared to subjects without risk factors (hazard ratio, 1.64; 95% CI, 1.18–2.30). Conclusion Controlling cardiovascular risk factors reduced the incidence of CVD events in patients with diabetes, especially those without cardio-renal disease. The degree of risk control was strongly associated with CVD mortality in patients with diabetes with baseline cardio-renal disease. © 2024 Song et al.
DOI
10.1371/journal.pone.0299035
Appears in Collections:
의과대학 > 의학과 > Journal papers
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