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Alterations in Gut Microbiota and Their Correlation with Brain Beta-Amyloid Burden Measured by 18F-Florbetaben PET in Mild Cognitive Impairment Due to Alzheimer’s Disease
- Title
- Alterations in Gut Microbiota and Their Correlation with Brain Beta-Amyloid Burden Measured by 18F-Florbetaben PET in Mild Cognitive Impairment Due to Alzheimer’s Disease
- Authors
- Kim; Geon Ha; Bori R.; Yoon; Hai-Jeon; Jeong; Jee Hyang
- Ewha Authors
- 정지향; 김건하; 윤혜전; 김보리
- SCOPUS Author ID
- 정지향; 김건하; 윤혜전; 김보리
- Issue Date
- 2024
- Journal Title
- Journal of Clinical Medicine
- ISSN
- 2077-0383
- Citation
- Journal of Clinical Medicine vol. 13, no. 7
- Keywords
- amyloid; amyloid beta; gut microbiota; mild cognitive impairment; positron-emission tomography; standardized uptake value ratio
- Publisher
- Multidisciplinary Digital Publishing Institute (MDPI)
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- (1) Background: This study investigated changes in the gut microbial composition of individuals with mild cognitive impairment (MCI) due to Alzheimer’s disease (AD) and their relationship with positron emission tomography (PET) amyloid accumulation. (2) Methods: In total, 17 cognitively normal individuals without amyloid-beta (Aβ) accumulation (Aβ−NC) and 24 with Aβ-positive mild cognitive impairment (Aβ+MCI) who underwent 18F-florbetaben PET and fecal bacterial 16S ribosomal RNA gene sequencing were enrolled. The taxonomic compositions of the Aβ−NC and Aβ+MCI groups were compared. The abundance of taxa was correlated with the standardized uptake value ratio (SUVR), using generalized linear models. (3) Results: There were significant differences in microbiome richness (ACE, p = 0.034 and Chao1, p = 0.024), alpha diversity (Shannon, p = 0.039), and beta diversity (Bray–Curtis, p = 0.018 and Generalized UniFrac, p = 0.034) between the Aβ−NC and Aβ+MCI groups. The global SUVR was positively correlated with the genus Intestinibacter (q = 0.006) and negatively correlated with the genera Roseburia (q = 0.008) and Agathobaculum (q = 0.029). (4) Conclusions: In this study, we identified significant changes in the gut microbiota composition that occur in individuals with MCI due to AD. In particular, the correlation analysis results between PET amyloid burden and gut microbial abundance showed that amyloid deposition is associated with a reduction in specific taxa involved in butyrate production. © 2024 by the authors.
- DOI
- 10.3390/jcm13071944
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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